Peripheral Lung Squamous Carcinoma With ROS1 Rearrangement Sensitive to Crizotinib: A Case Report

ROS1 rearrangements have been identified as driver mutations, accounting for 1–2% of lung adenocarcinoma, but are extremely rare in case of lung squamous cell carcinoma. In this work, we report a lung squamous cell carcinoma in a patient with peripheral lung cancer radiological manifestation, harbor...

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Autores principales: Yang, Guangdie, Wang, Jie, Yao, Yinan, Zhao, Jun, Yu, Zheyan, Gao, Qiqi, Ye, Jiani, Ma, Wenjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256165/
https://www.ncbi.nlm.nih.gov/pubmed/34235088
http://dx.doi.org/10.3389/fonc.2021.703318
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author Yang, Guangdie
Wang, Jie
Yao, Yinan
Zhao, Jun
Yu, Zheyan
Gao, Qiqi
Ye, Jiani
Ma, Wenjiang
author_facet Yang, Guangdie
Wang, Jie
Yao, Yinan
Zhao, Jun
Yu, Zheyan
Gao, Qiqi
Ye, Jiani
Ma, Wenjiang
author_sort Yang, Guangdie
collection PubMed
description ROS1 rearrangements have been identified as driver mutations, accounting for 1–2% of lung adenocarcinoma, but are extremely rare in case of lung squamous cell carcinoma. In this work, we report a lung squamous cell carcinoma in a patient with peripheral lung cancer radiological manifestation, harboring ROS1 rearrangement, with high sensitivity to crizotinib. Our findings suggest that clinicians should pay more attention toward the occurrence of ROS1 rearrangements and the application of crizotinib for lung squamous cell carcinoma treatment.
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spelling pubmed-82561652021-07-06 Peripheral Lung Squamous Carcinoma With ROS1 Rearrangement Sensitive to Crizotinib: A Case Report Yang, Guangdie Wang, Jie Yao, Yinan Zhao, Jun Yu, Zheyan Gao, Qiqi Ye, Jiani Ma, Wenjiang Front Oncol Oncology ROS1 rearrangements have been identified as driver mutations, accounting for 1–2% of lung adenocarcinoma, but are extremely rare in case of lung squamous cell carcinoma. In this work, we report a lung squamous cell carcinoma in a patient with peripheral lung cancer radiological manifestation, harboring ROS1 rearrangement, with high sensitivity to crizotinib. Our findings suggest that clinicians should pay more attention toward the occurrence of ROS1 rearrangements and the application of crizotinib for lung squamous cell carcinoma treatment. Frontiers Media S.A. 2021-06-21 /pmc/articles/PMC8256165/ /pubmed/34235088 http://dx.doi.org/10.3389/fonc.2021.703318 Text en Copyright © 2021 Yang, Wang, Yao, Zhao, Yu, Gao, Ye and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yang, Guangdie
Wang, Jie
Yao, Yinan
Zhao, Jun
Yu, Zheyan
Gao, Qiqi
Ye, Jiani
Ma, Wenjiang
Peripheral Lung Squamous Carcinoma With ROS1 Rearrangement Sensitive to Crizotinib: A Case Report
title Peripheral Lung Squamous Carcinoma With ROS1 Rearrangement Sensitive to Crizotinib: A Case Report
title_full Peripheral Lung Squamous Carcinoma With ROS1 Rearrangement Sensitive to Crizotinib: A Case Report
title_fullStr Peripheral Lung Squamous Carcinoma With ROS1 Rearrangement Sensitive to Crizotinib: A Case Report
title_full_unstemmed Peripheral Lung Squamous Carcinoma With ROS1 Rearrangement Sensitive to Crizotinib: A Case Report
title_short Peripheral Lung Squamous Carcinoma With ROS1 Rearrangement Sensitive to Crizotinib: A Case Report
title_sort peripheral lung squamous carcinoma with ros1 rearrangement sensitive to crizotinib: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256165/
https://www.ncbi.nlm.nih.gov/pubmed/34235088
http://dx.doi.org/10.3389/fonc.2021.703318
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