A highly conserved pocket on PP2A‐B56 is required for hSgo1 binding and cohesion protection during mitosis

The shugoshin proteins are universal protectors of centromeric cohesin during mitosis and meiosis. The binding of human hSgo1 to the PP2A‐B56 phosphatase through a coiled‐coil (CC) region mediates cohesion protection during mitosis. Here we undertook a structure function analysis of the PP2A‐B56‐hSg...

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Detalles Bibliográficos
Autores principales: Ueki, Yumi, Hadders, Michael A, Weisser, Melanie B, Nasa, Isha, Sotelo‐Parrilla, Paula, Cressey, Lauren E, Gupta, Tanmay, Hertz, Emil P T, Kruse, Thomas, Montoya, Guillermo, Jeyaprakash, A Arockia, Kettenbach, Arminja, Lens, Susanne M A, Nilsson, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256288/
https://www.ncbi.nlm.nih.gov/pubmed/33973335
http://dx.doi.org/10.15252/embr.202052295

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