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Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy
AIM: To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). PATIENTS & METHODS: 213 patients were included. INCLUSION CRITERIA: Nonmetastatic, M...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Future Science Ltd
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256323/ https://www.ncbi.nlm.nih.gov/pubmed/34258022 http://dx.doi.org/10.2144/fsoa-2021-0008 |
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| author | Ferro, Matteo Babă, Dragoş-Florin de Cobelli, Ottavio Musi, Gennaro Lucarelli, Giuseppe Terracciano, Daniela Porreca, Angelo Busetto, Gian Maria Del Giudice, Francesco Soria, Francesco Gontero, Paolo Cantiello, Francesco Damiano, Rocco Rocco, Papalia Scarpa, Roberto Mario Abu Farhan, Abdal Rahman Autorino, Riccardo Brescia, Antonio Marchioni, Michele Mari, Andrea Minervini, Andrea Longo, Nicola Chiancone, Francesco Perdona’, Sisto Barone, Biagio Placido, Pietro De Catellani, Michele Bottero, Danilo Ditonno, Pasquale Battaglia, Michele Zamboni, Stefania Antonelli, Alessandro Greco, Francesco Russo, Giorgio Ivan Smelzo, Salvatore Hurle, Rodolfo Crisan, Nicolae Manfredi, Matteo Porpiglia, Francesco Crocetto, Felice Buonerba, Carlo Danilesco, Alina Vartolomei, Mihai Dorin |
| author_facet | Ferro, Matteo Babă, Dragoş-Florin de Cobelli, Ottavio Musi, Gennaro Lucarelli, Giuseppe Terracciano, Daniela Porreca, Angelo Busetto, Gian Maria Del Giudice, Francesco Soria, Francesco Gontero, Paolo Cantiello, Francesco Damiano, Rocco Rocco, Papalia Scarpa, Roberto Mario Abu Farhan, Abdal Rahman Autorino, Riccardo Brescia, Antonio Marchioni, Michele Mari, Andrea Minervini, Andrea Longo, Nicola Chiancone, Francesco Perdona’, Sisto Barone, Biagio Placido, Pietro De Catellani, Michele Bottero, Danilo Ditonno, Pasquale Battaglia, Michele Zamboni, Stefania Antonelli, Alessandro Greco, Francesco Russo, Giorgio Ivan Smelzo, Salvatore Hurle, Rodolfo Crisan, Nicolae Manfredi, Matteo Porpiglia, Francesco Crocetto, Felice Buonerba, Carlo Danilesco, Alina Vartolomei, Mihai Dorin |
| author_sort | Ferro, Matteo |
| collection | PubMed |
| description | AIM: To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). PATIENTS & METHODS: 213 patients were included. INCLUSION CRITERIA: Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC. RESULTS: Five-years overall survival (OS) with NPAR >18 was 34.06% (95% CI: 18.3–50.5) and 65.37% (95% CI: 52.4–75.6) with NPAR <18. Five years cancer-specific survival (CSS) with NPAR >18 was 42.9% (95% CI: 23.9–60.7) and 74.5% (95% CI: 62.6–83.1) with NPAR <18 (p < 0.001). In multivariable analysis, NPAR increased OS of 1.3 points and CSS of 4.37 points. CONCLUSION: High NPAR prior to NAC seems to be a strong predictor of OS and CSS in MIBC patients treated with NAC and RC. |
| format | Online Article Text |
| id | pubmed-8256323 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Future Science Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82563232021-07-12 Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy Ferro, Matteo Babă, Dragoş-Florin de Cobelli, Ottavio Musi, Gennaro Lucarelli, Giuseppe Terracciano, Daniela Porreca, Angelo Busetto, Gian Maria Del Giudice, Francesco Soria, Francesco Gontero, Paolo Cantiello, Francesco Damiano, Rocco Rocco, Papalia Scarpa, Roberto Mario Abu Farhan, Abdal Rahman Autorino, Riccardo Brescia, Antonio Marchioni, Michele Mari, Andrea Minervini, Andrea Longo, Nicola Chiancone, Francesco Perdona’, Sisto Barone, Biagio Placido, Pietro De Catellani, Michele Bottero, Danilo Ditonno, Pasquale Battaglia, Michele Zamboni, Stefania Antonelli, Alessandro Greco, Francesco Russo, Giorgio Ivan Smelzo, Salvatore Hurle, Rodolfo Crisan, Nicolae Manfredi, Matteo Porpiglia, Francesco Crocetto, Felice Buonerba, Carlo Danilesco, Alina Vartolomei, Mihai Dorin Future Sci OA Research Article AIM: To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). PATIENTS & METHODS: 213 patients were included. INCLUSION CRITERIA: Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC. RESULTS: Five-years overall survival (OS) with NPAR >18 was 34.06% (95% CI: 18.3–50.5) and 65.37% (95% CI: 52.4–75.6) with NPAR <18. Five years cancer-specific survival (CSS) with NPAR >18 was 42.9% (95% CI: 23.9–60.7) and 74.5% (95% CI: 62.6–83.1) with NPAR <18 (p < 0.001). In multivariable analysis, NPAR increased OS of 1.3 points and CSS of 4.37 points. CONCLUSION: High NPAR prior to NAC seems to be a strong predictor of OS and CSS in MIBC patients treated with NAC and RC. Future Science Ltd 2021-04-20 /pmc/articles/PMC8256323/ /pubmed/34258022 http://dx.doi.org/10.2144/fsoa-2021-0008 Text en © 2021 Matteo Ferro https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) |
| spellingShingle | Research Article Ferro, Matteo Babă, Dragoş-Florin de Cobelli, Ottavio Musi, Gennaro Lucarelli, Giuseppe Terracciano, Daniela Porreca, Angelo Busetto, Gian Maria Del Giudice, Francesco Soria, Francesco Gontero, Paolo Cantiello, Francesco Damiano, Rocco Rocco, Papalia Scarpa, Roberto Mario Abu Farhan, Abdal Rahman Autorino, Riccardo Brescia, Antonio Marchioni, Michele Mari, Andrea Minervini, Andrea Longo, Nicola Chiancone, Francesco Perdona’, Sisto Barone, Biagio Placido, Pietro De Catellani, Michele Bottero, Danilo Ditonno, Pasquale Battaglia, Michele Zamboni, Stefania Antonelli, Alessandro Greco, Francesco Russo, Giorgio Ivan Smelzo, Salvatore Hurle, Rodolfo Crisan, Nicolae Manfredi, Matteo Porpiglia, Francesco Crocetto, Felice Buonerba, Carlo Danilesco, Alina Vartolomei, Mihai Dorin Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy |
| title | Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy |
| title_full | Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy |
| title_fullStr | Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy |
| title_full_unstemmed | Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy |
| title_short | Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy |
| title_sort | neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256323/ https://www.ncbi.nlm.nih.gov/pubmed/34258022 http://dx.doi.org/10.2144/fsoa-2021-0008 |
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