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Organoid models of the tumor microenvironment and their applications

A small percentage of data obtained from animal/2D culture models can be translated to humans. Therefore, there is a need to using native tumour microenvironment mimicking models to improve preclinical screening and reduce this attrition rate. For this purpose, currently, the utilization of organoid...

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Detalles Bibliográficos
Autores principales: Xia, Tao, Du, Wen‐Lin, Chen, Xiao‐Yi, Zhang, You‐Ni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256354/
https://www.ncbi.nlm.nih.gov/pubmed/34033245
http://dx.doi.org/10.1111/jcmm.16578
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author Xia, Tao
Du, Wen‐Lin
Chen, Xiao‐Yi
Zhang, You‐Ni
author_facet Xia, Tao
Du, Wen‐Lin
Chen, Xiao‐Yi
Zhang, You‐Ni
author_sort Xia, Tao
collection PubMed
description A small percentage of data obtained from animal/2D culture models can be translated to humans. Therefore, there is a need to using native tumour microenvironment mimicking models to improve preclinical screening and reduce this attrition rate. For this purpose, currently, the utilization of organoids is expanding. Tumour organoids can recapitulate tumour microenvironment that is including cancer cells and non‐neoplastic host components. Indeed, tumour organoids, both phenotypically and genetically, resemble the tumour tissue that originated from it. The unique properties of the tumour microenvironment can significantly affect drug response and cancer progression. In this review, we will discuss about various organoid culture strategies for modelling the tumour immune microenvironment, their applications and advantages in cancer research such as testing cancer immunotherapeutics, developing novel approaches for personalized medicine, testing drug toxicity, drug screening, study cancer initiation and progression, and we will also review the limitations of organoid culture systems.
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spelling pubmed-82563542021-07-12 Organoid models of the tumor microenvironment and their applications Xia, Tao Du, Wen‐Lin Chen, Xiao‐Yi Zhang, You‐Ni J Cell Mol Med Reviews A small percentage of data obtained from animal/2D culture models can be translated to humans. Therefore, there is a need to using native tumour microenvironment mimicking models to improve preclinical screening and reduce this attrition rate. For this purpose, currently, the utilization of organoids is expanding. Tumour organoids can recapitulate tumour microenvironment that is including cancer cells and non‐neoplastic host components. Indeed, tumour organoids, both phenotypically and genetically, resemble the tumour tissue that originated from it. The unique properties of the tumour microenvironment can significantly affect drug response and cancer progression. In this review, we will discuss about various organoid culture strategies for modelling the tumour immune microenvironment, their applications and advantages in cancer research such as testing cancer immunotherapeutics, developing novel approaches for personalized medicine, testing drug toxicity, drug screening, study cancer initiation and progression, and we will also review the limitations of organoid culture systems. John Wiley and Sons Inc. 2021-05-25 2021-07 /pmc/articles/PMC8256354/ /pubmed/34033245 http://dx.doi.org/10.1111/jcmm.16578 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Xia, Tao
Du, Wen‐Lin
Chen, Xiao‐Yi
Zhang, You‐Ni
Organoid models of the tumor microenvironment and their applications
title Organoid models of the tumor microenvironment and their applications
title_full Organoid models of the tumor microenvironment and their applications
title_fullStr Organoid models of the tumor microenvironment and their applications
title_full_unstemmed Organoid models of the tumor microenvironment and their applications
title_short Organoid models of the tumor microenvironment and their applications
title_sort organoid models of the tumor microenvironment and their applications
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256354/
https://www.ncbi.nlm.nih.gov/pubmed/34033245
http://dx.doi.org/10.1111/jcmm.16578
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