Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics

The mitochondrion is an organelle that plays a vital role in energy production, cytoplasmic protein degradation and cell death. Mitophagy is an autophagic procedure that specifically clears damaged mitochondria and maintains its homeostasis. Emerging evidence indicates that mitophagy is involved in...

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Autores principales: Guan, Yanjie, Wang, Yifei, Li, Bo, Shen, Kai, Li, Quanfu, Ni, Yingyin, Huang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256582/
https://www.ncbi.nlm.nih.gov/pubmed/34225732
http://dx.doi.org/10.1186/s12935-021-02065-w
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author Guan, Yanjie
Wang, Yifei
Li, Bo
Shen, Kai
Li, Quanfu
Ni, Yingyin
Huang, Lei
author_facet Guan, Yanjie
Wang, Yifei
Li, Bo
Shen, Kai
Li, Quanfu
Ni, Yingyin
Huang, Lei
author_sort Guan, Yanjie
collection PubMed
description The mitochondrion is an organelle that plays a vital role in energy production, cytoplasmic protein degradation and cell death. Mitophagy is an autophagic procedure that specifically clears damaged mitochondria and maintains its homeostasis. Emerging evidence indicates that mitophagy is involved in many physiological processes, including cellular homeostasis, cellular differentiation and nerve protection. In this review, we describe the regulatory mechanisms of mitophagy in mammals and yeasts and highlight the recent advances relevant to its function in carcinogenesis and drug resistance. Finally, a section has been dedicated to describing the role of mitophagy in anticancer therapeutics, which is a new frontier that offers a precise and promising strategy.
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spelling pubmed-82565822021-07-06 Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics Guan, Yanjie Wang, Yifei Li, Bo Shen, Kai Li, Quanfu Ni, Yingyin Huang, Lei Cancer Cell Int Review The mitochondrion is an organelle that plays a vital role in energy production, cytoplasmic protein degradation and cell death. Mitophagy is an autophagic procedure that specifically clears damaged mitochondria and maintains its homeostasis. Emerging evidence indicates that mitophagy is involved in many physiological processes, including cellular homeostasis, cellular differentiation and nerve protection. In this review, we describe the regulatory mechanisms of mitophagy in mammals and yeasts and highlight the recent advances relevant to its function in carcinogenesis and drug resistance. Finally, a section has been dedicated to describing the role of mitophagy in anticancer therapeutics, which is a new frontier that offers a precise and promising strategy. BioMed Central 2021-07-05 /pmc/articles/PMC8256582/ /pubmed/34225732 http://dx.doi.org/10.1186/s12935-021-02065-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Guan, Yanjie
Wang, Yifei
Li, Bo
Shen, Kai
Li, Quanfu
Ni, Yingyin
Huang, Lei
Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics
title Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics
title_full Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics
title_fullStr Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics
title_full_unstemmed Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics
title_short Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics
title_sort mitophagy in carcinogenesis, drug resistance and anticancer therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256582/
https://www.ncbi.nlm.nih.gov/pubmed/34225732
http://dx.doi.org/10.1186/s12935-021-02065-w
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