Cargando…

A high-resolution in vivo atlas of the human brain’s benzodiazepine binding site of GABA(A) receptors

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human brain and plays a key role in several brain functions and neuropsychiatric disorders such as anxiety, epilepsy, and depression. For decades, several in vivo and ex vivo techniques have been used to highlight the mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nørgaard, Martin, Beliveau, Vincent, Ganz, Melanie, Svarer, Claus, Pinborg, Lars H, Keller, Sune H, Jensen, Peter S, Greve, Douglas N., Knudsen, Gitte M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256681/ https://www.ncbi.nlm.nih.gov/pubmed/33610745 http://dx.doi.org/10.1016/j.neuroimage.2021.117878

Ejemplares similares

Brain Networks Implicated in Seasonal Affective Disorder: A Neuroimaging PET Study of the Serotonin Transporter
por: Nørgaard, Martin, et al.
Publicado: (2017)

Influence of GABA(A) Receptor α Subunit Isoforms on the Benzodiazepine Binding Site
por: Lüscher, Benjamin P., et al.
Publicado: (2012)

A Unified Model of the GABA(A) Receptor Comprising Agonist and Benzodiazepine Binding Sites
por: Bergmann, Rikke, et al.
Publicado: (2013)

Design of Infusion Schemes for Neuroreceptor Imaging: Application to [(11)C]Flumazenil-PET Steady-State Study
por: Feng, Ling, et al.
Publicado: (2016)

Visual stimuli induce serotonin release in occipital cortex: A simultaneous positron emission tomography/magnetic resonance imaging study
por: Hansen, Hanne Demant, et al.
Publicado: (2020)

Generalizability of treatment outcome prediction in major depressive disorder using structural MRI: A NeuroPharm study
por: Beliveau, Vincent, et al.
Publicado: (2022)

Benzodiazepine Modulation of GABA(A) Receptors: A Mechanistic Perspective
por: Goldschen-Ohm, Marcel P.
Publicado: (2022)

GABA(A) receptor subtypes and benzodiazepine use, misuse, and abuse
por: Engin, Elif
Publicado: (2023)

Stress Hormone Dynamics Are Coupled to Brain Serotonin 4 Receptor Availability in Unmedicated Patients With Major Depressive Disorder: A NeuroPharm Study
por: Vulpius, Gunild M, et al.
Publicado: (2023)

Benzodiazepines modulate GABA(A )receptors by reducing a gamma-subunit-mediated inhibition of GABA sensitivity
por: Baburin, Igor, et al.
Publicado: (2009)

Context Dependent Benzodiazepine Modulation of GABA(A) Receptor Opening Frequency
por: Bianchi, Matt T
Publicado: (2010)

Different Benzodiazepines Bind with Distinct Binding Modes to GABA(A) Receptors
por: Elgarf, Alshaimaa A., et al.
Publicado: (2018)

A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model
por: Clayton, Terry, et al.
Publicado: (2015)

Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA(A) Receptor
por: Yabuki, Yasushi, et al.
Publicado: (2020)

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABA(A) receptor subtype
por: Ralvenius, William T., et al.
Publicado: (2015)

Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABA(A) Receptors
por: Lian, Jing-Jing, et al.
Publicado: (2020)

The blood-to-plasma ratio and predicted GABA(A)-binding affinity of designer benzodiazepines
por: Manchester, Kieran R., et al.
Publicado: (2022)

FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia
por: Nyeng, Pia, et al.
Publicado: (2008)

Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines
por: Liu, Yan-Mei, et al.
Publicado: (2017)

Striatal D(2/3) Binding Potential Values in Drug-Naïve First-Episode Schizophrenia Patients Correlate With Treatment Outcome
por: Wulff, Sanne, et al.
Publicado: (2015)

Frontal D(2/3) Receptor Availability in Schizophrenia Patients Before and After Their First Antipsychotic Treatment: Relation to Cognitive Functions and Psychopathology
por: Nørbak-Emig, Henrik, et al.
Publicado: (2016)

Deep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort
por: Jensen, Kristian Høj Reveles, et al.
Publicado: (2023)

Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising γ1 or γ2 subunits
por: Baburin, I, et al.
Publicado: (2008)

A nonequilibrium binary elements-based kinetic model for benzodiazepine regulation of GABA(A) receptors
por: Goldschen-Ohm, Marcel P., et al.
Publicado: (2014)

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication
por: Wang, Guoying, et al.
Publicado: (2021)

Characterisation of Children's Head Motion for Magnetic Resonance Imaging With and Without General Anaesthesia
por: Eichhorn, Hannah, et al.
Publicado: (2021)

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABA(A) receptor in complex with GABA
por: Phulera, Swastik, et al.
Publicado: (2018)

Association between brain serotonin 4 receptor binding and reactivity to emotional faces in depressed and healthy individuals
por: Sankar, Anjali, et al.
Publicado: (2023)

Mechanisms Underlying Tolerance after Long-Term Benzodiazepine Use: A Future for Subtype-Selective GABA(A) Receptor Modulators?
por: Vinkers, Christiaan H., et al.
Publicado: (2012)

Functional Characterization of the 1,5-Benzodiazepine Clobazam and Its Major Active Metabolite N-Desmethylclobazam at Human GABA(A) Receptors Expressed in Xenopus laevis Oocytes
por: Hammer, Harriet, et al.
Publicado: (2015)

GABA transient sets the susceptibility of mIPSCs to modulation by benzodiazepine receptor agonists in rat hippocampal neurons
por: Mozrzymas, Jerzy W, et al.
Publicado: (2007)

Modulating native GABA(A) receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death
por: Kallay, Laura, et al.
Publicado: (2019)

High-Dose Benzodiazepines Positively Modulate GABA(A) Receptors via a Flumazenil-Insensitive Mechanism
por: Wang, Na, et al.
Publicado: (2021)

Striatal Volume Increase After Six Weeks of Selective Dopamine D(2/3) Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients
por: Andersen, Helle G., et al.
Publicado: (2020)

Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [(11)C]Ro15-4513 PET images
por: Myers, James FM, et al.
Publicado: (2012)

Valium without dependence? Individual GABA(A) receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects
por: Cheng, Tianze, et al.
Publicado: (2018)

GABA(A)/Benzodiazepine Receptor Complex in the Dorsal Hippocampus Mediates the Effects of Chrysin on Anxiety-Like Behaviour in Female Rats
por: Rodríguez-Landa, Juan Francisco, et al.
Publicado: (2022)

The Anxiolytic-like Properties of a Tryptic Hydrolysate of Bovine α(s1) Casein Containing α-Casozepine Rely on GABA(A) Receptor Benzodiazepine Binding Sites but Not the Vagus Nerve
por: Benoit, Simon, et al.
Publicado: (2022)

The Impact of Hormonal Contraceptive Use on Serotonergic Neurotransmission and Antidepressant Treatment Response: Results From the NeuroPharm 1 Study
por: Larsen, Søren Vinther, et al.
Publicado: (2022)

Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABA(A) receptors: evidence of a novel benzodiazepine site in the α1-α1 interface
por: Che Has, Ahmad Tarmizi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qsq5dglsak74ocoe3dj03o594u