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Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps

Triosephosphate isomerase (TIM) is a key enzyme in glycolysis that catalyses the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. This simple reaction involves the shuttling of protons mediated by protolysable side chains. The catalytic power of TIM is thought to stem f...

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Detalles Bibliográficos
Autores principales:	Kelpšas, Vinardas, Caldararu, Octav, Blakeley, Matthew P., Coquelle, Nicolas, Wierenga, Rikkert K., Ryde, Ulf, von Wachenfeldt, Claes, Oksanen, Esko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2021
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256706/ https://www.ncbi.nlm.nih.gov/pubmed/34258011 http://dx.doi.org/10.1107/S2052252521004619

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