Early rise in brain damage markers and high ICOS expression in CD4+ and CD8+ T cells during checkpoint inhibitor-induced encephalomyelitis

We report a case of rapid eradication of melanoma brain metastases and simultaneous near-fatal encephalomyelitis following double immune checkpoint blockade. Brain damage marker S-100B and C reactive protein increased before symptoms or signs of encephalomyelitis and peaked when the patient fell int...

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Detalles Bibliográficos
Autores principales: Bjursten, Sara, Pandita, Ankur, Zhao, Zhiyuan, Fröjd, Charlotta, Ny, Lars, Jensen, Christer, Ullerstam, Tobias, Jespersen, Henrik, Borén, Jan, Levin, Malin, Zetterberg, Henrik, Rudin, Anna, Levin, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256743/
https://www.ncbi.nlm.nih.gov/pubmed/34215689
http://dx.doi.org/10.1136/jitc-2021-002732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256743/
https://www.ncbi.nlm.nih.gov/pubmed/34215689
http://dx.doi.org/10.1136/jitc-2021-002732

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