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Reduction in self-reported influenza-like-illness in school children and household members following influenza vaccine administration – a cohort study, Israel, 2016–7

BACKGROUND: Second-grade pupils in Israel have been vaccinated against influenza since the winter of 2016–2017. This study aims to appraise the rate reduction of seasonal influenza vaccine among vaccinated children and their household members, and that of the vaccinated cohort and their household me...

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Autores principales: Shviro Roseman, Noa, Bilenko, Natalya, Sheffer, Rivka, Mor, Zohar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256775/
https://www.ncbi.nlm.nih.gov/pubmed/34225814
http://dx.doi.org/10.1186/s13584-021-00478-6
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author Shviro Roseman, Noa
Bilenko, Natalya
Sheffer, Rivka
Mor, Zohar
author_facet Shviro Roseman, Noa
Bilenko, Natalya
Sheffer, Rivka
Mor, Zohar
author_sort Shviro Roseman, Noa
collection PubMed
description BACKGROUND: Second-grade pupils in Israel have been vaccinated against influenza since the winter of 2016–2017. This study aims to appraise the rate reduction of seasonal influenza vaccine among vaccinated children and their household members, and that of the vaccinated cohort and their household members. METHODS: This retrospective cohort study was performed in winter 2016–2017 in Tel-Aviv District, Israel and compared second-grade pupils who were vaccinated at school, with third-grade pupils- who were not vaccinated at school. Parents in nine schools were asked to report prior vaccination against influenza and influenza-like illness (ILI) of their children and other household members. Rate reduction was defined as [(ILI among unvaccinated) – (ILI among vaccinated)] / (ILI among vaccinated) (%). RESULTS: Of 527 participants, 359 (68.1%) were unvaccinated and 168 (31.9%) vaccinated. Unvaccinated children reported more ILI compared with vaccinated children (19.5% vs. 7.7%), yielding a rate reduction of 60.5%. Unvaccinated children also had a greater number of physicians’ visits and missed school days (35.7% vs. 14.9 and 42.9% vs. 25.6%, respectively). The rate of ILI among household members of unvaccinated children was 34.5%, compared with 25.0% among household members of vaccinated children. The vaccinated cohort (defined as all children in second grade) reported less ILI compared with the unvaccinated cohort (defined as all children in third grade), with a rate reduction of 44.6%. Pupils of the unvaccinated cohort were more likely to miss school days (42.1% vs. 32.0%, respectively), and a higher rate of ILI was reported among household members of the unvaccinated cohort (35.4% vs. 27.3%, respectively). CONCLUSION: Influenza vaccine administered in school setting reduced ILI among the vaccinated cohort and their household members by 60.5 and 27.5%, respectively, compared with the unvaccinated cohort. Expansion of the vaccination program in a school setting increased the public health benefit of influenza vaccines among both school children and their household members.
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spelling pubmed-82567752021-07-06 Reduction in self-reported influenza-like-illness in school children and household members following influenza vaccine administration – a cohort study, Israel, 2016–7 Shviro Roseman, Noa Bilenko, Natalya Sheffer, Rivka Mor, Zohar Isr J Health Policy Res Original Research Article BACKGROUND: Second-grade pupils in Israel have been vaccinated against influenza since the winter of 2016–2017. This study aims to appraise the rate reduction of seasonal influenza vaccine among vaccinated children and their household members, and that of the vaccinated cohort and their household members. METHODS: This retrospective cohort study was performed in winter 2016–2017 in Tel-Aviv District, Israel and compared second-grade pupils who were vaccinated at school, with third-grade pupils- who were not vaccinated at school. Parents in nine schools were asked to report prior vaccination against influenza and influenza-like illness (ILI) of their children and other household members. Rate reduction was defined as [(ILI among unvaccinated) – (ILI among vaccinated)] / (ILI among vaccinated) (%). RESULTS: Of 527 participants, 359 (68.1%) were unvaccinated and 168 (31.9%) vaccinated. Unvaccinated children reported more ILI compared with vaccinated children (19.5% vs. 7.7%), yielding a rate reduction of 60.5%. Unvaccinated children also had a greater number of physicians’ visits and missed school days (35.7% vs. 14.9 and 42.9% vs. 25.6%, respectively). The rate of ILI among household members of unvaccinated children was 34.5%, compared with 25.0% among household members of vaccinated children. The vaccinated cohort (defined as all children in second grade) reported less ILI compared with the unvaccinated cohort (defined as all children in third grade), with a rate reduction of 44.6%. Pupils of the unvaccinated cohort were more likely to miss school days (42.1% vs. 32.0%, respectively), and a higher rate of ILI was reported among household members of the unvaccinated cohort (35.4% vs. 27.3%, respectively). CONCLUSION: Influenza vaccine administered in school setting reduced ILI among the vaccinated cohort and their household members by 60.5 and 27.5%, respectively, compared with the unvaccinated cohort. Expansion of the vaccination program in a school setting increased the public health benefit of influenza vaccines among both school children and their household members. BioMed Central 2021-07-05 /pmc/articles/PMC8256775/ /pubmed/34225814 http://dx.doi.org/10.1186/s13584-021-00478-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Original Research Article
Shviro Roseman, Noa
Bilenko, Natalya
Sheffer, Rivka
Mor, Zohar
Reduction in self-reported influenza-like-illness in school children and household members following influenza vaccine administration – a cohort study, Israel, 2016–7
title Reduction in self-reported influenza-like-illness in school children and household members following influenza vaccine administration – a cohort study, Israel, 2016–7
title_full Reduction in self-reported influenza-like-illness in school children and household members following influenza vaccine administration – a cohort study, Israel, 2016–7
title_fullStr Reduction in self-reported influenza-like-illness in school children and household members following influenza vaccine administration – a cohort study, Israel, 2016–7
title_full_unstemmed Reduction in self-reported influenza-like-illness in school children and household members following influenza vaccine administration – a cohort study, Israel, 2016–7
title_short Reduction in self-reported influenza-like-illness in school children and household members following influenza vaccine administration – a cohort study, Israel, 2016–7
title_sort reduction in self-reported influenza-like-illness in school children and household members following influenza vaccine administration – a cohort study, israel, 2016–7
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256775/
https://www.ncbi.nlm.nih.gov/pubmed/34225814
http://dx.doi.org/10.1186/s13584-021-00478-6
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