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STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation

BACKGROUND: Resistance to an immune checkpoint inhibitor (ICI) is a major obstacle in cancer immunotherapy. The causes of ICI resistance include major histocompatibility complex (MHC)/histocompatibility locus antigen (HLA) class I loss, neoantigen loss, and incomplete antigen presentation. Eliminati...

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Detalles Bibliográficos
Autores principales:	Nakamura, Takashi, Sato, Takanori, Endo, Rikito, Sasaki, Shun, Takahashi, Naomichi, Sato, Yusuke, Hyodo, Mamoru, Hayakawa, Yoshihiro, Harashima, Hideyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256839/ https://www.ncbi.nlm.nih.gov/pubmed/34215690 http://dx.doi.org/10.1136/jitc-2021-002852

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