Deep sequencing of 1320 genes reveals the landscape of protein-truncating variants and their contribution to psoriasis in 19,973 Chinese individuals

Protein-truncating variants (PTVs) have important impacts on phenotype diversity and disease. However, their population genetics characteristics in more globally diverse populations are not well defined. Here, we describe patterns of PTVs in 1320 genes sequenced in 10,539 healthy controls and 9434 p...

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Detalles Bibliográficos
Autores principales: Xu, Huixin, Zhen, Qi, Bai, Mingzhou, Fang, Lin, Zhang, Yong, Li, Bao, Ge, Huiyao, Moon, Sunjin, Chen, Weiwei, Fu, Wenqing, Xu, Qiongqiong, Zhou, Yuwen, Yu, Yafeng, Lin, Long, Yong, Liang, Zhang, Tao, Chen, Shirui, Liu, Siyang, Zhang, Hui, Chen, Ruoyan, Cao, Lu, Zhang, Yuanwei, Zhang, Ruixue, Yang, Huanjie, Hu, Xia, Akey, Joshua M., Jin, Xin, Sun, Liangdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256863/
https://www.ncbi.nlm.nih.gov/pubmed/34155038
http://dx.doi.org/10.1101/gr.267963.120

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