Cargando…
Radiographic Hepatic Steatosis Is Not Associated With Key Clinical Outcomes Among Patients Hospitalized With COVID-19
BACKGROUND: Metabolic syndrome increases adverse outcomes in coronavirus disease 2019 (COVID-19) infection. Hepatic steatosis may increase risk of COVID-19 severity. Current studies evaluating steatosis lack reliable definitions. We aimed to evaluate the association of radiographic hepatic steatosis...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256898/ https://www.ncbi.nlm.nih.gov/pubmed/34267833 http://dx.doi.org/10.14740/gr1389 |
_version_ | 1783718190175485952 |
---|---|
author | Trivedi, Hirsh D. Wilechansky, Robert Goyes, Daniela Vieira Barbosa, Joana Canakis, Andrew Lai, Michelle Long, Michelle T. Fricker, Zachary |
author_facet | Trivedi, Hirsh D. Wilechansky, Robert Goyes, Daniela Vieira Barbosa, Joana Canakis, Andrew Lai, Michelle Long, Michelle T. Fricker, Zachary |
author_sort | Trivedi, Hirsh D. |
collection | PubMed |
description | BACKGROUND: Metabolic syndrome increases adverse outcomes in coronavirus disease 2019 (COVID-19) infection. Hepatic steatosis may increase risk of COVID-19 severity. Current studies evaluating steatosis lack reliable definitions. We aimed to evaluate the association of radiographic hepatic steatosis and clinical outcomes of COVID-19 severity in a diverse cohort. METHODS: We retrospectively identified patients with COVID-19 infection admitted to two US academic hospitals. Outcomes were length of stay, intensive care unit use, mechanical ventilation, and in-hospital mortality. We used Mann-Whitney U-test for continuous measures and Chi-square or Fisher’s exact test for categorical measures. Multivariable linear and logistic regression analyses were used to adjust for confounders. RESULTS: Of the 319 patients, 14% had hepatic steatosis. There were no differences in length of stay (6 (4 - 16) vs. 9 (4 - 18) days, P = 0.6), intensive care unit (24% vs. 32%, P = 0.3), mechanical ventilation (28% vs. 38%, P = 0.32), or in-hospital mortality (7% vs. 17%, P = 0.12). After adjustment, there was no difference in length of stay (β: -14.37, 95% confidence interval (CI): -30.5 - 1.77, P = 0.08), intensive care unit (odds ratio (OR): 0.31, 95% CI: 0.03 - 1.09, P = 0.06), mechanical ventilation (OR: 0.13, 95% CI: 0.02 - 1.09, P = 0.06), or in-hospital mortality (OR: 0.27, 95% CI: 0.06 - 1.16, P = 0.08) among patients with hepatic steatosis. CONCLUSION: Radiographic hepatic steatosis was not associated with worse outcomes among patients hospitalized with COVID-19. |
format | Online Article Text |
id | pubmed-8256898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82568982021-07-14 Radiographic Hepatic Steatosis Is Not Associated With Key Clinical Outcomes Among Patients Hospitalized With COVID-19 Trivedi, Hirsh D. Wilechansky, Robert Goyes, Daniela Vieira Barbosa, Joana Canakis, Andrew Lai, Michelle Long, Michelle T. Fricker, Zachary Gastroenterology Res Original Article BACKGROUND: Metabolic syndrome increases adverse outcomes in coronavirus disease 2019 (COVID-19) infection. Hepatic steatosis may increase risk of COVID-19 severity. Current studies evaluating steatosis lack reliable definitions. We aimed to evaluate the association of radiographic hepatic steatosis and clinical outcomes of COVID-19 severity in a diverse cohort. METHODS: We retrospectively identified patients with COVID-19 infection admitted to two US academic hospitals. Outcomes were length of stay, intensive care unit use, mechanical ventilation, and in-hospital mortality. We used Mann-Whitney U-test for continuous measures and Chi-square or Fisher’s exact test for categorical measures. Multivariable linear and logistic regression analyses were used to adjust for confounders. RESULTS: Of the 319 patients, 14% had hepatic steatosis. There were no differences in length of stay (6 (4 - 16) vs. 9 (4 - 18) days, P = 0.6), intensive care unit (24% vs. 32%, P = 0.3), mechanical ventilation (28% vs. 38%, P = 0.32), or in-hospital mortality (7% vs. 17%, P = 0.12). After adjustment, there was no difference in length of stay (β: -14.37, 95% confidence interval (CI): -30.5 - 1.77, P = 0.08), intensive care unit (odds ratio (OR): 0.31, 95% CI: 0.03 - 1.09, P = 0.06), mechanical ventilation (OR: 0.13, 95% CI: 0.02 - 1.09, P = 0.06), or in-hospital mortality (OR: 0.27, 95% CI: 0.06 - 1.16, P = 0.08) among patients with hepatic steatosis. CONCLUSION: Radiographic hepatic steatosis was not associated with worse outcomes among patients hospitalized with COVID-19. Elmer Press 2021-06 2021-06-19 /pmc/articles/PMC8256898/ /pubmed/34267833 http://dx.doi.org/10.14740/gr1389 Text en Copyright 2021, Trivedi et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Trivedi, Hirsh D. Wilechansky, Robert Goyes, Daniela Vieira Barbosa, Joana Canakis, Andrew Lai, Michelle Long, Michelle T. Fricker, Zachary Radiographic Hepatic Steatosis Is Not Associated With Key Clinical Outcomes Among Patients Hospitalized With COVID-19 |
title | Radiographic Hepatic Steatosis Is Not Associated With Key Clinical Outcomes Among Patients Hospitalized With COVID-19 |
title_full | Radiographic Hepatic Steatosis Is Not Associated With Key Clinical Outcomes Among Patients Hospitalized With COVID-19 |
title_fullStr | Radiographic Hepatic Steatosis Is Not Associated With Key Clinical Outcomes Among Patients Hospitalized With COVID-19 |
title_full_unstemmed | Radiographic Hepatic Steatosis Is Not Associated With Key Clinical Outcomes Among Patients Hospitalized With COVID-19 |
title_short | Radiographic Hepatic Steatosis Is Not Associated With Key Clinical Outcomes Among Patients Hospitalized With COVID-19 |
title_sort | radiographic hepatic steatosis is not associated with key clinical outcomes among patients hospitalized with covid-19 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256898/ https://www.ncbi.nlm.nih.gov/pubmed/34267833 http://dx.doi.org/10.14740/gr1389 |
work_keys_str_mv | AT trivedihirshd radiographichepaticsteatosisisnotassociatedwithkeyclinicaloutcomesamongpatientshospitalizedwithcovid19 AT wilechanskyrobert radiographichepaticsteatosisisnotassociatedwithkeyclinicaloutcomesamongpatientshospitalizedwithcovid19 AT goyesdaniela radiographichepaticsteatosisisnotassociatedwithkeyclinicaloutcomesamongpatientshospitalizedwithcovid19 AT vieirabarbosajoana radiographichepaticsteatosisisnotassociatedwithkeyclinicaloutcomesamongpatientshospitalizedwithcovid19 AT canakisandrew radiographichepaticsteatosisisnotassociatedwithkeyclinicaloutcomesamongpatientshospitalizedwithcovid19 AT laimichelle radiographichepaticsteatosisisnotassociatedwithkeyclinicaloutcomesamongpatientshospitalizedwithcovid19 AT longmichellet radiographichepaticsteatosisisnotassociatedwithkeyclinicaloutcomesamongpatientshospitalizedwithcovid19 AT frickerzachary radiographichepaticsteatosisisnotassociatedwithkeyclinicaloutcomesamongpatientshospitalizedwithcovid19 |