Cargando…

Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age

Objective: To investigate the rate and stability of impairments in children born preterm by assessing (1) early and school-age outcome in four developmental domains and (2) individual changes in outcome at both timepoints. Design: Prospective, longitudinal cohort study in children born in 2006–2007,...

Descripción completa

Detalles Bibliográficos
Autores principales: Jansen, Lisette, Peeters-Scholte, Cacha M. P. C. D., van den Berg-Huysmans, Annette A., van Klink, Jeanine M. M., Rijken, Monique, van Egmond-van Dam, Janneke C., Vermeiren, Robert R. J. M., Steggerda, Sylke J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257021/
https://www.ncbi.nlm.nih.gov/pubmed/34235124
http://dx.doi.org/10.3389/fped.2021.674221
_version_ 1783718218444046336
author Jansen, Lisette
Peeters-Scholte, Cacha M. P. C. D.
van den Berg-Huysmans, Annette A.
van Klink, Jeanine M. M.
Rijken, Monique
van Egmond-van Dam, Janneke C.
Vermeiren, Robert R. J. M.
Steggerda, Sylke J.
author_facet Jansen, Lisette
Peeters-Scholte, Cacha M. P. C. D.
van den Berg-Huysmans, Annette A.
van Klink, Jeanine M. M.
Rijken, Monique
van Egmond-van Dam, Janneke C.
Vermeiren, Robert R. J. M.
Steggerda, Sylke J.
author_sort Jansen, Lisette
collection PubMed
description Objective: To investigate the rate and stability of impairments in children born preterm by assessing (1) early and school-age outcome in four developmental domains and (2) individual changes in outcome at both timepoints. Design: Prospective, longitudinal cohort study in children born in 2006–2007, <32 weeks' gestation. Follow-up at 2 and 10 years of age included standardized neurological, motor, cognitive and behavioral assessments. Children were categorized as having no, mild or moderate-severe impairment in these four domains. A composite impairment score was composed and the number of domains with impairments counted. For each child, individual outcomes at both timepoints were compared. Results: Follow-up at both time-points was available in 71/113(63%) children. At group level, there were no significant changes in the severity of impairments per domain. However, at individual level, there were less children with a mild abnormal composite score at 10 years of age (44 vs. 20%; p = 0.006), and more with a moderate-severe abnormal composite score (12 vs. 35%; p = 0.001). Especially children with normal/mild outcome at 2 years were likely to shift to other outcome categories over time. Conclusions: Children with early severe impairment are likely experiencing impairments later on, but early normal/mild abnormal outcomes should be interpreted with care, considering the large individual shifts over time. Long-term follow-up in all children born very preterm should therefore be continued to at least school-age.
format Online
Article
Text
id pubmed-8257021
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82570212021-07-06 Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age Jansen, Lisette Peeters-Scholte, Cacha M. P. C. D. van den Berg-Huysmans, Annette A. van Klink, Jeanine M. M. Rijken, Monique van Egmond-van Dam, Janneke C. Vermeiren, Robert R. J. M. Steggerda, Sylke J. Front Pediatr Pediatrics Objective: To investigate the rate and stability of impairments in children born preterm by assessing (1) early and school-age outcome in four developmental domains and (2) individual changes in outcome at both timepoints. Design: Prospective, longitudinal cohort study in children born in 2006–2007, <32 weeks' gestation. Follow-up at 2 and 10 years of age included standardized neurological, motor, cognitive and behavioral assessments. Children were categorized as having no, mild or moderate-severe impairment in these four domains. A composite impairment score was composed and the number of domains with impairments counted. For each child, individual outcomes at both timepoints were compared. Results: Follow-up at both time-points was available in 71/113(63%) children. At group level, there were no significant changes in the severity of impairments per domain. However, at individual level, there were less children with a mild abnormal composite score at 10 years of age (44 vs. 20%; p = 0.006), and more with a moderate-severe abnormal composite score (12 vs. 35%; p = 0.001). Especially children with normal/mild outcome at 2 years were likely to shift to other outcome categories over time. Conclusions: Children with early severe impairment are likely experiencing impairments later on, but early normal/mild abnormal outcomes should be interpreted with care, considering the large individual shifts over time. Long-term follow-up in all children born very preterm should therefore be continued to at least school-age. Frontiers Media S.A. 2021-06-21 /pmc/articles/PMC8257021/ /pubmed/34235124 http://dx.doi.org/10.3389/fped.2021.674221 Text en Copyright © 2021 Jansen, Peeters-Scholte, Berg-Huysmans, Klink, Rijken, Egmond-van Dam, Vermeiren and Steggerda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Jansen, Lisette
Peeters-Scholte, Cacha M. P. C. D.
van den Berg-Huysmans, Annette A.
van Klink, Jeanine M. M.
Rijken, Monique
van Egmond-van Dam, Janneke C.
Vermeiren, Robert R. J. M.
Steggerda, Sylke J.
Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age
title Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age
title_full Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age
title_fullStr Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age
title_full_unstemmed Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age
title_short Longitudinal Follow-Up of Children Born Preterm: Neurodevelopment From 2 to 10 Years of Age
title_sort longitudinal follow-up of children born preterm: neurodevelopment from 2 to 10 years of age
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257021/
https://www.ncbi.nlm.nih.gov/pubmed/34235124
http://dx.doi.org/10.3389/fped.2021.674221
work_keys_str_mv AT jansenlisette longitudinalfollowupofchildrenbornpretermneurodevelopmentfrom2to10yearsofage
AT peetersscholtecachampcd longitudinalfollowupofchildrenbornpretermneurodevelopmentfrom2to10yearsofage
AT vandenberghuysmansannettea longitudinalfollowupofchildrenbornpretermneurodevelopmentfrom2to10yearsofage
AT vanklinkjeaninemm longitudinalfollowupofchildrenbornpretermneurodevelopmentfrom2to10yearsofage
AT rijkenmonique longitudinalfollowupofchildrenbornpretermneurodevelopmentfrom2to10yearsofage
AT vanegmondvandamjannekec longitudinalfollowupofchildrenbornpretermneurodevelopmentfrom2to10yearsofage
AT vermeirenrobertrjm longitudinalfollowupofchildrenbornpretermneurodevelopmentfrom2to10yearsofage
AT steggerdasylkej longitudinalfollowupofchildrenbornpretermneurodevelopmentfrom2to10yearsofage