Cargando…
Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia
INTRODUCTION: This study assessed the association of cerebral ischemia with neurodegeneration in mild cognitive impairment (MCI) and dementia. METHODS: Subjects with MCI, dementia and controls underwent assessment of cognitive function, severity of brain ischemia, MRI brain volumetry and corneal con...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257078/ https://www.ncbi.nlm.nih.gov/pubmed/34234643 http://dx.doi.org/10.3389/fnins.2021.690896 |
| _version_ | 1783718230361112576 |
|---|---|
| author | Ponirakis, Georgios Elsotouhy, Ahmed Al Hamad, Hanadi Vattoth, Surjith Petropoulos, Ioannis N. Khan, Adnan Gad, Hoda Al-Khayat, Fatima Chandran, Mani Ramadan, Marwan Elorrabi, Marwa Gadelseed, Masharig Tosino, Rhia Gawhale, Priya V. Alobaidi, Maryam Khan, Shafi Manikoth, Pravija Abdelrahim, Yasmin H. M. Thodi, Noushad Almuhannadi, Hamad Al-Mohannadi, Salma AlMarri, Fatema Qazi, Murtaza Own, Ahmed Mahfoud, Ziyad R. Shuaib, Ashfaq Malik, Rayaz A. |
| author_facet | Ponirakis, Georgios Elsotouhy, Ahmed Al Hamad, Hanadi Vattoth, Surjith Petropoulos, Ioannis N. Khan, Adnan Gad, Hoda Al-Khayat, Fatima Chandran, Mani Ramadan, Marwan Elorrabi, Marwa Gadelseed, Masharig Tosino, Rhia Gawhale, Priya V. Alobaidi, Maryam Khan, Shafi Manikoth, Pravija Abdelrahim, Yasmin H. M. Thodi, Noushad Almuhannadi, Hamad Al-Mohannadi, Salma AlMarri, Fatema Qazi, Murtaza Own, Ahmed Mahfoud, Ziyad R. Shuaib, Ashfaq Malik, Rayaz A. |
| author_sort | Ponirakis, Georgios |
| collection | PubMed |
| description | INTRODUCTION: This study assessed the association of cerebral ischemia with neurodegeneration in mild cognitive impairment (MCI) and dementia. METHODS: Subjects with MCI, dementia and controls underwent assessment of cognitive function, severity of brain ischemia, MRI brain volumetry and corneal confocal microscopy. RESULTS: Of 63 subjects with MCI (n = 44) and dementia (n = 19), 11 had no ischemia, 32 had subcortical ischemia and 20 had both subcortical and cortical ischemia. Brain volume and corneal nerve measures were comparable between subjects with subcortical ischemia and no ischemia. However, subjects with subcortical and cortical ischemia had a lower hippocampal volume (P < 0.01), corneal nerve fiber length (P < 0.05) and larger ventricular volume (P < 0.05) compared to those with subcortical ischemia and lower corneal nerve fiber density (P < 0.05) compared to those without ischemia. DISCUSSION: Cerebral ischemia was associated with cognitive impairment, brain atrophy and corneal nerve loss in MCI and dementia. |
| format | Online Article Text |
| id | pubmed-8257078 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82570782021-07-06 Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia Ponirakis, Georgios Elsotouhy, Ahmed Al Hamad, Hanadi Vattoth, Surjith Petropoulos, Ioannis N. Khan, Adnan Gad, Hoda Al-Khayat, Fatima Chandran, Mani Ramadan, Marwan Elorrabi, Marwa Gadelseed, Masharig Tosino, Rhia Gawhale, Priya V. Alobaidi, Maryam Khan, Shafi Manikoth, Pravija Abdelrahim, Yasmin H. M. Thodi, Noushad Almuhannadi, Hamad Al-Mohannadi, Salma AlMarri, Fatema Qazi, Murtaza Own, Ahmed Mahfoud, Ziyad R. Shuaib, Ashfaq Malik, Rayaz A. Front Neurosci Neuroscience INTRODUCTION: This study assessed the association of cerebral ischemia with neurodegeneration in mild cognitive impairment (MCI) and dementia. METHODS: Subjects with MCI, dementia and controls underwent assessment of cognitive function, severity of brain ischemia, MRI brain volumetry and corneal confocal microscopy. RESULTS: Of 63 subjects with MCI (n = 44) and dementia (n = 19), 11 had no ischemia, 32 had subcortical ischemia and 20 had both subcortical and cortical ischemia. Brain volume and corneal nerve measures were comparable between subjects with subcortical ischemia and no ischemia. However, subjects with subcortical and cortical ischemia had a lower hippocampal volume (P < 0.01), corneal nerve fiber length (P < 0.05) and larger ventricular volume (P < 0.05) compared to those with subcortical ischemia and lower corneal nerve fiber density (P < 0.05) compared to those without ischemia. DISCUSSION: Cerebral ischemia was associated with cognitive impairment, brain atrophy and corneal nerve loss in MCI and dementia. Frontiers Media S.A. 2021-06-21 /pmc/articles/PMC8257078/ /pubmed/34234643 http://dx.doi.org/10.3389/fnins.2021.690896 Text en Copyright © 2021 Ponirakis, Elsotouhy, Al Hamad, Vattoth, Petropoulos, Khan, Gad, Al-Khayat, Chandran, Ramadan, Elorrabi, Gadelseed, Tosino, Gawhale, Alobaidi, Khan, Manikoth, Abdelrahim, Thodi, Almuhannadi, Al-Mohannadi, AlMarri, Qazi, Own, Mahfoud, Shuaib and Malik. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Neuroscience Ponirakis, Georgios Elsotouhy, Ahmed Al Hamad, Hanadi Vattoth, Surjith Petropoulos, Ioannis N. Khan, Adnan Gad, Hoda Al-Khayat, Fatima Chandran, Mani Ramadan, Marwan Elorrabi, Marwa Gadelseed, Masharig Tosino, Rhia Gawhale, Priya V. Alobaidi, Maryam Khan, Shafi Manikoth, Pravija Abdelrahim, Yasmin H. M. Thodi, Noushad Almuhannadi, Hamad Al-Mohannadi, Salma AlMarri, Fatema Qazi, Murtaza Own, Ahmed Mahfoud, Ziyad R. Shuaib, Ashfaq Malik, Rayaz A. Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_full | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_fullStr | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_full_unstemmed | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_short | Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia |
| title_sort | association of cerebral ischemia with corneal nerve loss and brain atrophy in mci and dementia |
| topic | Neuroscience |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257078/ https://www.ncbi.nlm.nih.gov/pubmed/34234643 http://dx.doi.org/10.3389/fnins.2021.690896 |
| work_keys_str_mv | AT ponirakisgeorgios associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT elsotouhyahmed associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT alhamadhanadi associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT vattothsurjith associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT petropoulosioannisn associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT khanadnan associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT gadhoda associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT alkhayatfatima associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT chandranmani associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT ramadanmarwan associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT elorrabimarwa associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT gadelseedmasharig associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT tosinorhia associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT gawhalepriyav associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT alobaidimaryam associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT khanshafi associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT manikothpravija associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT abdelrahimyasminhm associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT thodinoushad associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT almuhannadihamad associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT almohannadisalma associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT almarrifatema associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT qazimurtaza associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT ownahmed associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT mahfoudziyadr associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT shuaibashfaq associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia AT malikrayaza associationofcerebralischemiawithcornealnervelossandbrainatrophyinmcianddementia |