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Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet

INTRODUCTION: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and...

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Autores principales: Siqueira, Juliana Silva, Francisqueti-Ferron, Fabiane Valentini, Garcia, Jéssica Leite, Silva, Carol Cristina Vágula de Almeida, Costa, Mariane Róvero, Nakandakare-Maia, Erika Tiemi, Moreto, Fernando, Ferreira, Ana Lúcia A., Minatel, Igor Otávio, Ferron, Artur Junio Togneri, Corrêa, Camila Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Nefrologia 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257273/
https://www.ncbi.nlm.nih.gov/pubmed/33475676
http://dx.doi.org/10.1590/2175-8239-JBN-2020-0169
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author Siqueira, Juliana Silva
Francisqueti-Ferron, Fabiane Valentini
Garcia, Jéssica Leite
Silva, Carol Cristina Vágula de Almeida
Costa, Mariane Róvero
Nakandakare-Maia, Erika Tiemi
Moreto, Fernando
Ferreira, Ana Lúcia A.
Minatel, Igor Otávio
Ferron, Artur Junio Togneri
Corrêa, Camila Renata
author_facet Siqueira, Juliana Silva
Francisqueti-Ferron, Fabiane Valentini
Garcia, Jéssica Leite
Silva, Carol Cristina Vágula de Almeida
Costa, Mariane Róvero
Nakandakare-Maia, Erika Tiemi
Moreto, Fernando
Ferreira, Ana Lúcia A.
Minatel, Igor Otávio
Ferron, Artur Junio Togneri
Corrêa, Camila Renata
author_sort Siqueira, Juliana Silva
collection PubMed
description INTRODUCTION: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this study was to evaluate the preventive effect of RB on renal disease risk factors. METHODS: Male Wistar rats (±325 g) were divided into two experimental groups to received a high sugar-fat diet (HSF, n = 8) or high sugar-fat diet with rice bran (HSF + RB, n = 8) for 20 weeks. At the end, renal function, body composition, metabolic parameters, renal inflammatory and oxidative stress markers were analyzed. RESULTS: RB prevented obesity [AI (HSF= 9.92 ± 1.19 vs HSF + RB= 6.62 ± 0.78)], insulin resistance [HOMA (HSF= 83 ± 8 vs. HSF + RB= 42 ± 11)], dyslipidemia [TG (HSF= 167 ± 41 vs. HSF + RB=92 ± 40)], inflammation [TNF-α (HSF= 80 ± 12 vs. HSF + RB=57 ± 14), IL-6 (903 ± 274 vs. HSF + RB=535 ± 277)], oxidative stress [protein carbonylation (HSF= 3.38 ± 0.18 vs. HSF + RB=2.68 ± 0.29), RAGE (HSF=702 ± 36 vs. RSF + RB=570 ± 190)], and renal disease [protein/creatinine ratio (HSF=1.10 ± 0.38 vs. HSF + RB=0.49 ± 0.16)]. CONCLUSION: In conclusion, rice bran prevented renal disease by modulating risk factors.
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spelling pubmed-82572732021-07-16 Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet Siqueira, Juliana Silva Francisqueti-Ferron, Fabiane Valentini Garcia, Jéssica Leite Silva, Carol Cristina Vágula de Almeida Costa, Mariane Róvero Nakandakare-Maia, Erika Tiemi Moreto, Fernando Ferreira, Ana Lúcia A. Minatel, Igor Otávio Ferron, Artur Junio Togneri Corrêa, Camila Renata J Bras Nefrol Original Article INTRODUCTION: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this study was to evaluate the preventive effect of RB on renal disease risk factors. METHODS: Male Wistar rats (±325 g) were divided into two experimental groups to received a high sugar-fat diet (HSF, n = 8) or high sugar-fat diet with rice bran (HSF + RB, n = 8) for 20 weeks. At the end, renal function, body composition, metabolic parameters, renal inflammatory and oxidative stress markers were analyzed. RESULTS: RB prevented obesity [AI (HSF= 9.92 ± 1.19 vs HSF + RB= 6.62 ± 0.78)], insulin resistance [HOMA (HSF= 83 ± 8 vs. HSF + RB= 42 ± 11)], dyslipidemia [TG (HSF= 167 ± 41 vs. HSF + RB=92 ± 40)], inflammation [TNF-α (HSF= 80 ± 12 vs. HSF + RB=57 ± 14), IL-6 (903 ± 274 vs. HSF + RB=535 ± 277)], oxidative stress [protein carbonylation (HSF= 3.38 ± 0.18 vs. HSF + RB=2.68 ± 0.29), RAGE (HSF=702 ± 36 vs. RSF + RB=570 ± 190)], and renal disease [protein/creatinine ratio (HSF=1.10 ± 0.38 vs. HSF + RB=0.49 ± 0.16)]. CONCLUSION: In conclusion, rice bran prevented renal disease by modulating risk factors. Sociedade Brasileira de Nefrologia 2021-01-15 2021 /pmc/articles/PMC8257273/ /pubmed/33475676 http://dx.doi.org/10.1590/2175-8239-JBN-2020-0169 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Siqueira, Juliana Silva
Francisqueti-Ferron, Fabiane Valentini
Garcia, Jéssica Leite
Silva, Carol Cristina Vágula de Almeida
Costa, Mariane Róvero
Nakandakare-Maia, Erika Tiemi
Moreto, Fernando
Ferreira, Ana Lúcia A.
Minatel, Igor Otávio
Ferron, Artur Junio Togneri
Corrêa, Camila Renata
Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet
title Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet
title_full Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet
title_fullStr Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet
title_full_unstemmed Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet
title_short Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet
title_sort rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257273/
https://www.ncbi.nlm.nih.gov/pubmed/33475676
http://dx.doi.org/10.1590/2175-8239-JBN-2020-0169
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