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Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet
INTRODUCTION: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Nefrologia
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257273/ https://www.ncbi.nlm.nih.gov/pubmed/33475676 http://dx.doi.org/10.1590/2175-8239-JBN-2020-0169 |
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author | Siqueira, Juliana Silva Francisqueti-Ferron, Fabiane Valentini Garcia, Jéssica Leite Silva, Carol Cristina Vágula de Almeida Costa, Mariane Róvero Nakandakare-Maia, Erika Tiemi Moreto, Fernando Ferreira, Ana Lúcia A. Minatel, Igor Otávio Ferron, Artur Junio Togneri Corrêa, Camila Renata |
author_facet | Siqueira, Juliana Silva Francisqueti-Ferron, Fabiane Valentini Garcia, Jéssica Leite Silva, Carol Cristina Vágula de Almeida Costa, Mariane Róvero Nakandakare-Maia, Erika Tiemi Moreto, Fernando Ferreira, Ana Lúcia A. Minatel, Igor Otávio Ferron, Artur Junio Togneri Corrêa, Camila Renata |
author_sort | Siqueira, Juliana Silva |
collection | PubMed |
description | INTRODUCTION: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this study was to evaluate the preventive effect of RB on renal disease risk factors. METHODS: Male Wistar rats (±325 g) were divided into two experimental groups to received a high sugar-fat diet (HSF, n = 8) or high sugar-fat diet with rice bran (HSF + RB, n = 8) for 20 weeks. At the end, renal function, body composition, metabolic parameters, renal inflammatory and oxidative stress markers were analyzed. RESULTS: RB prevented obesity [AI (HSF= 9.92 ± 1.19 vs HSF + RB= 6.62 ± 0.78)], insulin resistance [HOMA (HSF= 83 ± 8 vs. HSF + RB= 42 ± 11)], dyslipidemia [TG (HSF= 167 ± 41 vs. HSF + RB=92 ± 40)], inflammation [TNF-α (HSF= 80 ± 12 vs. HSF + RB=57 ± 14), IL-6 (903 ± 274 vs. HSF + RB=535 ± 277)], oxidative stress [protein carbonylation (HSF= 3.38 ± 0.18 vs. HSF + RB=2.68 ± 0.29), RAGE (HSF=702 ± 36 vs. RSF + RB=570 ± 190)], and renal disease [protein/creatinine ratio (HSF=1.10 ± 0.38 vs. HSF + RB=0.49 ± 0.16)]. CONCLUSION: In conclusion, rice bran prevented renal disease by modulating risk factors. |
format | Online Article Text |
id | pubmed-8257273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira de Nefrologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-82572732021-07-16 Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet Siqueira, Juliana Silva Francisqueti-Ferron, Fabiane Valentini Garcia, Jéssica Leite Silva, Carol Cristina Vágula de Almeida Costa, Mariane Róvero Nakandakare-Maia, Erika Tiemi Moreto, Fernando Ferreira, Ana Lúcia A. Minatel, Igor Otávio Ferron, Artur Junio Togneri Corrêa, Camila Renata J Bras Nefrol Original Article INTRODUCTION: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this study was to evaluate the preventive effect of RB on renal disease risk factors. METHODS: Male Wistar rats (±325 g) were divided into two experimental groups to received a high sugar-fat diet (HSF, n = 8) or high sugar-fat diet with rice bran (HSF + RB, n = 8) for 20 weeks. At the end, renal function, body composition, metabolic parameters, renal inflammatory and oxidative stress markers were analyzed. RESULTS: RB prevented obesity [AI (HSF= 9.92 ± 1.19 vs HSF + RB= 6.62 ± 0.78)], insulin resistance [HOMA (HSF= 83 ± 8 vs. HSF + RB= 42 ± 11)], dyslipidemia [TG (HSF= 167 ± 41 vs. HSF + RB=92 ± 40)], inflammation [TNF-α (HSF= 80 ± 12 vs. HSF + RB=57 ± 14), IL-6 (903 ± 274 vs. HSF + RB=535 ± 277)], oxidative stress [protein carbonylation (HSF= 3.38 ± 0.18 vs. HSF + RB=2.68 ± 0.29), RAGE (HSF=702 ± 36 vs. RSF + RB=570 ± 190)], and renal disease [protein/creatinine ratio (HSF=1.10 ± 0.38 vs. HSF + RB=0.49 ± 0.16)]. CONCLUSION: In conclusion, rice bran prevented renal disease by modulating risk factors. Sociedade Brasileira de Nefrologia 2021-01-15 2021 /pmc/articles/PMC8257273/ /pubmed/33475676 http://dx.doi.org/10.1590/2175-8239-JBN-2020-0169 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Siqueira, Juliana Silva Francisqueti-Ferron, Fabiane Valentini Garcia, Jéssica Leite Silva, Carol Cristina Vágula de Almeida Costa, Mariane Róvero Nakandakare-Maia, Erika Tiemi Moreto, Fernando Ferreira, Ana Lúcia A. Minatel, Igor Otávio Ferron, Artur Junio Togneri Corrêa, Camila Renata Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet |
title | Rice bran modulates renal disease risk factors in animals submitted
to high sugar-fat diet |
title_full | Rice bran modulates renal disease risk factors in animals submitted
to high sugar-fat diet |
title_fullStr | Rice bran modulates renal disease risk factors in animals submitted
to high sugar-fat diet |
title_full_unstemmed | Rice bran modulates renal disease risk factors in animals submitted
to high sugar-fat diet |
title_short | Rice bran modulates renal disease risk factors in animals submitted
to high sugar-fat diet |
title_sort | rice bran modulates renal disease risk factors in animals submitted
to high sugar-fat diet |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257273/ https://www.ncbi.nlm.nih.gov/pubmed/33475676 http://dx.doi.org/10.1590/2175-8239-JBN-2020-0169 |
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