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A stochastic SEIHR model for COVID-19 data fluctuations

Although deterministic compartmental models are useful for predicting the general trend of a disease’s spread, they are unable to describe the random daily fluctuations in the number of new infections and hospitalizations, which is crucial in determining the necessary healthcare capacity for a speci...

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Autores principales: Niu, Ruiwu, Chan, Yin-Chi, Wong, Eric W. M., van Wyk, Michaël Antonie, Chen, Guanrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257466/
https://www.ncbi.nlm.nih.gov/pubmed/34248280
http://dx.doi.org/10.1007/s11071-021-06631-9
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author Niu, Ruiwu
Chan, Yin-Chi
Wong, Eric W. M.
van Wyk, Michaël Antonie
Chen, Guanrong
author_facet Niu, Ruiwu
Chan, Yin-Chi
Wong, Eric W. M.
van Wyk, Michaël Antonie
Chen, Guanrong
author_sort Niu, Ruiwu
collection PubMed
description Although deterministic compartmental models are useful for predicting the general trend of a disease’s spread, they are unable to describe the random daily fluctuations in the number of new infections and hospitalizations, which is crucial in determining the necessary healthcare capacity for a specified level of risk. In this paper, we propose a stochastic SEIHR (sSEIHR) model to describe such random fluctuations and provide sufficient conditions for stochastic stability of the disease-free equilibrium, based on the basic reproduction number that we estimated. Our extensive numerical results demonstrate strong threshold behavior near the estimated basic reproduction number, suggesting that the necessary conditions for stochastic stability are close to the sufficient conditions derived. Furthermore, we found that increasing the noise level slightly reduces the final proportion of infected individuals. In addition, we analyze COVID-19 data from various regions worldwide and demonstrate that by changing only a few parameter values, our sSEIHR model can accurately describe both the general trend and the random fluctuations in the number of daily new cases in each region, allowing governments and hospitals to make more accurate caseload predictions using fewer compartments and parameters than other comparable stochastic compartmental models.
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spelling pubmed-82574662021-07-06 A stochastic SEIHR model for COVID-19 data fluctuations Niu, Ruiwu Chan, Yin-Chi Wong, Eric W. M. van Wyk, Michaël Antonie Chen, Guanrong Nonlinear Dyn Original Paper Although deterministic compartmental models are useful for predicting the general trend of a disease’s spread, they are unable to describe the random daily fluctuations in the number of new infections and hospitalizations, which is crucial in determining the necessary healthcare capacity for a specified level of risk. In this paper, we propose a stochastic SEIHR (sSEIHR) model to describe such random fluctuations and provide sufficient conditions for stochastic stability of the disease-free equilibrium, based on the basic reproduction number that we estimated. Our extensive numerical results demonstrate strong threshold behavior near the estimated basic reproduction number, suggesting that the necessary conditions for stochastic stability are close to the sufficient conditions derived. Furthermore, we found that increasing the noise level slightly reduces the final proportion of infected individuals. In addition, we analyze COVID-19 data from various regions worldwide and demonstrate that by changing only a few parameter values, our sSEIHR model can accurately describe both the general trend and the random fluctuations in the number of daily new cases in each region, allowing governments and hospitals to make more accurate caseload predictions using fewer compartments and parameters than other comparable stochastic compartmental models. Springer Netherlands 2021-07-06 2021 /pmc/articles/PMC8257466/ /pubmed/34248280 http://dx.doi.org/10.1007/s11071-021-06631-9 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Paper
Niu, Ruiwu
Chan, Yin-Chi
Wong, Eric W. M.
van Wyk, Michaël Antonie
Chen, Guanrong
A stochastic SEIHR model for COVID-19 data fluctuations
title A stochastic SEIHR model for COVID-19 data fluctuations
title_full A stochastic SEIHR model for COVID-19 data fluctuations
title_fullStr A stochastic SEIHR model for COVID-19 data fluctuations
title_full_unstemmed A stochastic SEIHR model for COVID-19 data fluctuations
title_short A stochastic SEIHR model for COVID-19 data fluctuations
title_sort stochastic seihr model for covid-19 data fluctuations
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257466/
https://www.ncbi.nlm.nih.gov/pubmed/34248280
http://dx.doi.org/10.1007/s11071-021-06631-9
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