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Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets

The oncogenic protein Bcr-Abl has two major isoforms, p190(Bcr-Abl) and p210(Bcr-Abl). While p210(Bcr-Abl) is the hallmark of chronic myeloid leukemia (CML), p190(Bcr-Abl) occurs in the majority of Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) patients. In CML, p190(Bcr-Abl) occurs i...

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Detalles Bibliográficos
Autores principales:	Adnan-Awad, Shady, Kim, Daehong, Hohtari, Helena, Javarappa, Komal Kumar, Brandstoetter, Tania, Mayer, Isabella, Potdar, Swapnil, Heckman, Caroline A., Kytölä, Soili, Porkka, Kimmo, Doma, Eszter, Sexl, Veronika, Kankainen, Matti, Mustjoki, Satu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257498/ https://www.ncbi.nlm.nih.gov/pubmed/33168949 http://dx.doi.org/10.1038/s41375-020-01082-4

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