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miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia
Pharmacological inhibition of MDM2/4, which activates the critical tumor suppressor p53, has been gaining increasing interest as a strategy for the treatment of acute myeloid leukemia (AML). While clinical trials of MDM2 inhibitors have shown promise, responses have been confined to largely molecula...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257503/ https://www.ncbi.nlm.nih.gov/pubmed/33262524 http://dx.doi.org/10.1038/s41375-020-01095-z |