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Efficient TALEN-mediated gene knockin at the bovine Y chromosome and generation of a sex-reversal bovine
Functional elucidation of bovine Y-chromosome genes requires available genome editing technologies. Meanwhile, it has yet to be proven whether the bovine Sry gene is the main or single factor involved in the development of the male phenotype in bovine. Here, we efficiently knocked out four Y-linked...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257526/ https://www.ncbi.nlm.nih.gov/pubmed/34047803 http://dx.doi.org/10.1007/s00018-021-03855-1 |