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Cell migration guided by long-lived spatial memory

Living cells actively migrate in their environment to perform key biological functions—from unicellular organisms looking for food to single cells such as fibroblasts, leukocytes or cancer cells that can shape, patrol or invade tissues. Cell migration results from complex intracellular processes tha...

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Autores principales: d’Alessandro, Joseph, Barbier--Chebbah, Alex, Cellerin, Victor, Benichou, Olivier, Mège, René Marc, Voituriez, Raphaël, Ladoux, Benoît
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257581/
https://www.ncbi.nlm.nih.gov/pubmed/34226542
http://dx.doi.org/10.1038/s41467-021-24249-8
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author d’Alessandro, Joseph
Barbier--Chebbah, Alex
Cellerin, Victor
Benichou, Olivier
Mège, René Marc
Voituriez, Raphaël
Ladoux, Benoît
author_facet d’Alessandro, Joseph
Barbier--Chebbah, Alex
Cellerin, Victor
Benichou, Olivier
Mège, René Marc
Voituriez, Raphaël
Ladoux, Benoît
author_sort d’Alessandro, Joseph
collection PubMed
description Living cells actively migrate in their environment to perform key biological functions—from unicellular organisms looking for food to single cells such as fibroblasts, leukocytes or cancer cells that can shape, patrol or invade tissues. Cell migration results from complex intracellular processes that enable cell self-propulsion, and has been shown to also integrate various chemical or physical extracellular signals. While it is established that cells can modify their environment by depositing biochemical signals or mechanically remodelling the extracellular matrix, the impact of such self-induced environmental perturbations on cell trajectories at various scales remains unexplored. Here, we show that cells can retrieve their path: by confining motile cells on 1D and 2D micropatterned surfaces, we demonstrate that they leave long-lived physicochemical footprints along their way, which determine their future path. On this basis, we argue that cell trajectories belong to the general class of self-interacting random walks, and show that self-interactions can rule large scale exploration by inducing long-lived ageing, subdiffusion and anomalous first-passage statistics. Altogether, our joint experimental and theoretical approach points to a generic coupling between motile cells and their environment, which endows cells with a spatial memory of their path and can dramatically change their space exploration.
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spelling pubmed-82575812021-07-23 Cell migration guided by long-lived spatial memory d’Alessandro, Joseph Barbier--Chebbah, Alex Cellerin, Victor Benichou, Olivier Mège, René Marc Voituriez, Raphaël Ladoux, Benoît Nat Commun Article Living cells actively migrate in their environment to perform key biological functions—from unicellular organisms looking for food to single cells such as fibroblasts, leukocytes or cancer cells that can shape, patrol or invade tissues. Cell migration results from complex intracellular processes that enable cell self-propulsion, and has been shown to also integrate various chemical or physical extracellular signals. While it is established that cells can modify their environment by depositing biochemical signals or mechanically remodelling the extracellular matrix, the impact of such self-induced environmental perturbations on cell trajectories at various scales remains unexplored. Here, we show that cells can retrieve their path: by confining motile cells on 1D and 2D micropatterned surfaces, we demonstrate that they leave long-lived physicochemical footprints along their way, which determine their future path. On this basis, we argue that cell trajectories belong to the general class of self-interacting random walks, and show that self-interactions can rule large scale exploration by inducing long-lived ageing, subdiffusion and anomalous first-passage statistics. Altogether, our joint experimental and theoretical approach points to a generic coupling between motile cells and their environment, which endows cells with a spatial memory of their path and can dramatically change their space exploration. Nature Publishing Group UK 2021-07-05 /pmc/articles/PMC8257581/ /pubmed/34226542 http://dx.doi.org/10.1038/s41467-021-24249-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
d’Alessandro, Joseph
Barbier--Chebbah, Alex
Cellerin, Victor
Benichou, Olivier
Mège, René Marc
Voituriez, Raphaël
Ladoux, Benoît
Cell migration guided by long-lived spatial memory
title Cell migration guided by long-lived spatial memory
title_full Cell migration guided by long-lived spatial memory
title_fullStr Cell migration guided by long-lived spatial memory
title_full_unstemmed Cell migration guided by long-lived spatial memory
title_short Cell migration guided by long-lived spatial memory
title_sort cell migration guided by long-lived spatial memory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257581/
https://www.ncbi.nlm.nih.gov/pubmed/34226542
http://dx.doi.org/10.1038/s41467-021-24249-8
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