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miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells

Tumor endothelial cells (TECs) reportedly exhibit altered phenotypes. We have demonstrated that TECs acquire drug resistance with the upregulation of P-glycoprotein (P-gp, ABCB1), contrary to traditional assumptions. Furthermore, P-gp expression was higher in TECs of highly metastatic tumors than in...

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Detalles Bibliográficos
Autores principales:	Torii, Chisaho, Maishi, Nako, Kawamoto, Taisuke, Morimoto, Masahiro, Akiyama, Kosuke, Yoshioka, Yusuke, Minami, Takashi, Tsumita, Takuya, Alam, Mohammad Towfik, Ochiya, Takahiro, Hida, Yasuhiro, Hida, Kyoko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257582/ https://www.ncbi.nlm.nih.gov/pubmed/34226586 http://dx.doi.org/10.1038/s41598-021-92879-5

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