Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles

Effective treatments of neurodegenerative diseases require drugs to be actively transported across the blood-brain barrier (BBB). However, nanoparticle drug carriers explored for this purpose show negligible brain uptake, and the lack of basic understanding of nanoparticle-BBB interactions underlies...

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Detalles Bibliográficos
Autores principales: Kucharz, Krzysztof, Kristensen, Kasper, Johnsen, Kasper Bendix, Lund, Mette Aagaard, Lønstrup, Micael, Moos, Torben, Andresen, Thomas Lars, Lauritzen, Martin Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257611/
https://www.ncbi.nlm.nih.gov/pubmed/34226541
http://dx.doi.org/10.1038/s41467-021-24323-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257611/
https://www.ncbi.nlm.nih.gov/pubmed/34226541
http://dx.doi.org/10.1038/s41467-021-24323-1

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