Cargando…

Bromodomain protein BRDT directs ΔNp63 function and super-enhancer activity in a subset of esophageal squamous cell carcinomas

Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer with a particularly high prevalence in certain geographical regions and a poor prognosis with a 5-year survival rate of 15–25%. Despite numerous studies characterizing the genetic and transcriptomic landscape o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xin, Kutschat, Ana P., Yamada, Moyuru, Prokakis, Evangelos, Böttcher, Patricia, Tanaka, Koji, Doki, Yuichiro, Hamdan, Feda H., Johnsen, Steven A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257622/ https://www.ncbi.nlm.nih.gov/pubmed/33658703 http://dx.doi.org/10.1038/s41418-021-00751-w

Ejemplares similares

Discovery and characterization of bromodomain 2–specific inhibitors of BRDT
por: Yu, Zhifeng, et al.
Publicado: (2021)

ΔNp63 intronic miR-944 is implicated in the ΔNp63-mediated induction of epidermal differentiation
por: Kim, Kyu-Han, et al.
Publicado: (2015)

Store-Operated Calcium Entry: Shaping the Transcriptional and Epigenetic Landscape in Pancreatic Cancer
por: Kutschat, Ana P., et al.
Publicado: (2021)

Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes
por: Kimura, Shuhei, et al.
Publicado: (2015)

ΔNp63 drives epithelial differentiation in glioma
por: Lu, Jia‐Hao, et al.
Publicado: (2020)

A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT
por: Miller, Thomas C. R., et al.
Publicado: (2016)

The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target
por: Bourova-Flin, Ekaterina, et al.
Publicado: (2017)

The Bromodomain Testis-Specific Gene (Brdt) Characterization and Expression in Gilthead Seabream, Sparus Aurata, and European Seabass, Dicentrarchus Labrax
por: Úbeda-Manzanaro, M., et al.
Publicado: (2016)

ΔNp63 Is Essential for Epidermal Commitment of Embryonic Stem Cells
por: Medawar, Alain, et al.
Publicado: (2008)

ΔNp63 mediates cellular survival and metastasis in canine osteosarcoma
por: Cam, Maren, et al.
Publicado: (2016)

ΔNp63α-mediated epigenetic regulation in keratinocyte senescence
por: Kuang, Linghan, et al.
Publicado: (2023)

YAP Dysregulation by Phosphorylation or ΔNp63-mediated Gene Repression Promotes Proliferation, Survival and Migration in Head and Neck Cancer Subsets
por: Ehsanian, Reza, et al.
Publicado: (2010)

c-Abl phosphorylation of ΔNp63α is critical for cell viability
por: Yuan, M, et al.
Publicado: (2010)

A Hidden Role of the Inactivated FANCD2: Upregulating ΔNp63
por: Panneerselvam, Jayabal, et al.
Publicado: (2013)

Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma
por: Kumakura, Yuji, et al.
Publicado: (2017)

ΔNp63α and microRNAs: leveraging the epithelial-mesenchymal transition
por: Stacy, Andrew J., et al.
Publicado: (2016)

ΔNp63 to TAp63 expression ratio as a potential molecular marker for cervical cancer prognosis
por: Park, Sunyoung, et al.
Publicado: (2019)

DNA Demethylation Switches Oncogenic ΔNp63 to Tumor Suppressive TAp63 in Squamous Cell Carcinoma
por: Pokorna, Zuzana, et al.
Publicado: (2022)

Identification of novel potent human testis-specific and bromodomain-containing protein (BRDT) inhibitors using crystal structure-based virtual screening
por: GAO, NANA, et al.
Publicado: (2016)

Dual regulation of TERT activity through transcription and splicing by ΔNP63α
por: Vorovich, Esther, et al.
Publicado: (2008)

ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis
por: Rizzo, J M, et al.
Publicado: (2016)

Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis
por: Regina, Carla, et al.
Publicado: (2016)

Development of an integrated CRISPRi targeting ΔNp63 for treatment of squamous cell carcinoma
por: Yoshida, Masakazu, et al.
Publicado: (2018)

Tmub1 Suppresses Hepatocellular Carcinoma by Promoting the Ubiquitination of ΔNp63 Isoforms
por: Fu, Hangwei, et al.
Publicado: (2020)

ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells
por: Sato, Kota, et al.
Publicado: (2023)

Correction: ΔNp63 to TAp63 expression ratio as a potential molecular marker for cervical cancer prognosis
por: Park, Sunyoung, et al.
Publicado: (2019)

Small-Molecule Inhibition of BRDT for Male Contraception
por: Matzuk, Martin M., et al.
Publicado: (2012)

BRDT promotes ovarian cancer cell growth
por: Chen, Ling, et al.
Publicado: (2020)

ΔNp63α transcriptionally represses p53 target genes involved in the radiation-induced DNA damage response: ΔNp63α may cause genomic instability in epithelial stem cells
por: Kudo, Ken-ichi, et al.
Publicado: (2022)

Possible Involvement of the Upregulation of ΔNp63 Expression Mediated by HER2-Activated Aryl Hydrocarbon Receptor in Mammosphere Maintenance
por: Kanno, Yuichiro, et al.
Publicado: (2022)

ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation
por: Craig, Ashley L, et al.
Publicado: (2010)

Mechanistic and Treatment Implications of ΔNp63 Expression in a Rare Case of Metastatic Hidradenocarcinoma
por: Driscoll, James J., et al.
Publicado: (2009)

Tumor suppressor WWOX binds to ΔNp63α and sensitizes cancer cells to chemotherapy
por: Salah, Z, et al.
Publicado: (2013)

ΔNp63α Transcriptionally Regulates the Expression of CTEN That Is Associated with Prostate Cell Adhesion
por: Yang, Kuan, et al.
Publicado: (2016)

ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion
por: Dang, Tuyen T., et al.
Publicado: (2016)

ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells
por: Gatti, Veronica, et al.
Publicado: (2018)

DNA damage induces expression of WWP1 to target ΔNp63α to degradation
por: Chen, Ji, et al.
Publicado: (2017)

ΔNp63 is a pioneer factor that binds inaccessible chromatin and elicits chromatin remodeling
por: Yu, Xinyang, et al.
Publicado: (2021)

E47 upregulates ΔNp63α to promote growth of squamous cell carcinoma
por: Xu, Jing, et al.
Publicado: (2021)

ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells
por: Van Sciver, Nicholas, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pomg3q04sqlqvaumamqd06el6a