Cargando…
Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years
The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cognition te...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257625/ https://www.ncbi.nlm.nih.gov/pubmed/34226614 http://dx.doi.org/10.1038/s41598-021-93211-x |
_version_ | 1783718351430746112 |
---|---|
author | Müller, Bernhard W. Hinney, Anke Scherbaum, Norbert Weimar, Christian Kleinschnitz, Christoph Peters, Triinu Hochfeld, Lara Pechlivanis, Sonali Stang, Andreas Jokisch, Martha Kowall, Bernd |
author_facet | Müller, Bernhard W. Hinney, Anke Scherbaum, Norbert Weimar, Christian Kleinschnitz, Christoph Peters, Triinu Hochfeld, Lara Pechlivanis, Sonali Stang, Andreas Jokisch, Martha Kowall, Bernd |
author_sort | Müller, Bernhard W. |
collection | PubMed |
description | The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cognition tests (immediate and delayed word list, Trail-Making Test [TMT] part A and B, Maze test, interference condition of the Stroop color-word test, verbal fluency) and their associations with Klotho KL-VS haplotype. The Klotho KL-VS haplotype is classified by the V-allele at SNP rs9536314 (F352V) and the S-allele at SNP rs9527025 (C370S). Heterozygotes for the KL-VS haplotype were compared with non-carriers. Analyses were performed in 1812 subjects (55–87 years). We found consistent but only slightly lower performance in heterozygous carriers of the KL-VS haplotype in all tasks with Z-scores ranging between Z = − 0.042 (verbal fluency) and − 0.17 (TMT part A). Differences between carriers and non-carriers were similar for men and women for all tests but TMT part B (interaction contrast = 8.4 s (95% CI − 2.3; 19.1)). While cognition declined with age, we found an effect modification by age (55–65 years, 66–75 years, > 75 years). In the 66–75 years KL-VS heterozygous age group, lower performance was seen in memory, visual attention and motor speed. Contrary to our hypothesis, heterozygous carriers of the KL-VS haplotype did not show enhanced performance in cognitive tests in our study. |
format | Online Article Text |
id | pubmed-8257625 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82576252021-07-06 Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years Müller, Bernhard W. Hinney, Anke Scherbaum, Norbert Weimar, Christian Kleinschnitz, Christoph Peters, Triinu Hochfeld, Lara Pechlivanis, Sonali Stang, Andreas Jokisch, Martha Kowall, Bernd Sci Rep Article The heterozygous human Klotho KL-VS haplotype has been associated with improved cognitive performance but results are inconsistent. Here we assessed Klotho KL-VS haplotype and cognition using data from the third examination of the population-based Heinz Nixdorf Recall Study. We analyzed cognition tests (immediate and delayed word list, Trail-Making Test [TMT] part A and B, Maze test, interference condition of the Stroop color-word test, verbal fluency) and their associations with Klotho KL-VS haplotype. The Klotho KL-VS haplotype is classified by the V-allele at SNP rs9536314 (F352V) and the S-allele at SNP rs9527025 (C370S). Heterozygotes for the KL-VS haplotype were compared with non-carriers. Analyses were performed in 1812 subjects (55–87 years). We found consistent but only slightly lower performance in heterozygous carriers of the KL-VS haplotype in all tasks with Z-scores ranging between Z = − 0.042 (verbal fluency) and − 0.17 (TMT part A). Differences between carriers and non-carriers were similar for men and women for all tests but TMT part B (interaction contrast = 8.4 s (95% CI − 2.3; 19.1)). While cognition declined with age, we found an effect modification by age (55–65 years, 66–75 years, > 75 years). In the 66–75 years KL-VS heterozygous age group, lower performance was seen in memory, visual attention and motor speed. Contrary to our hypothesis, heterozygous carriers of the KL-VS haplotype did not show enhanced performance in cognitive tests in our study. Nature Publishing Group UK 2021-07-05 /pmc/articles/PMC8257625/ /pubmed/34226614 http://dx.doi.org/10.1038/s41598-021-93211-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Müller, Bernhard W. Hinney, Anke Scherbaum, Norbert Weimar, Christian Kleinschnitz, Christoph Peters, Triinu Hochfeld, Lara Pechlivanis, Sonali Stang, Andreas Jokisch, Martha Kowall, Bernd Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years |
title | Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years |
title_full | Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years |
title_fullStr | Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years |
title_full_unstemmed | Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years |
title_short | Klotho KL-VS haplotype does not improve cognition in a population-based sample of adults age 55–87 years |
title_sort | klotho kl-vs haplotype does not improve cognition in a population-based sample of adults age 55–87 years |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257625/ https://www.ncbi.nlm.nih.gov/pubmed/34226614 http://dx.doi.org/10.1038/s41598-021-93211-x |
work_keys_str_mv | AT mullerbernhardw klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT hinneyanke klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT scherbaumnorbert klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT weimarchristian klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT kleinschnitzchristoph klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT peterstriinu klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT hochfeldlara klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT pechlivanissonali klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT stangandreas klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT jokischmartha klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years AT kowallbernd klothoklvshaplotypedoesnotimprovecognitioninapopulationbasedsampleofadultsage5587years |