The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations

Chromosomal translocations of the AF10 (or MLLT10) gene are frequently found in acute leukemias. Here, we show that the PZP domain of AF10 (AF10(PZP)), which is consistently impaired or deleted in leukemogenic AF10 translocations, plays a critical role in blocking malignant transformation. Incorpora...

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Detalles Bibliográficos
Autores principales: Klein, Brianna J., Deshpande, Anagha, Cox, Khan L., Xuan, Fan, Zandian, Mohamad, Barbosa, Karina, Khanal, Sujita, Tong, Qiong, Zhang, Yi, Zhang, Pan, Sinha, Amit, Bohlander, Stefan K., Shi, Xiaobing, Wen, Hong, Poirier, Michael G., Deshpande, Aniruddha J., Kutateladze, Tatiana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257627/
https://www.ncbi.nlm.nih.gov/pubmed/34226546
http://dx.doi.org/10.1038/s41467-021-24418-9

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