Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

Cancer stem cells (CSCs) are tumor subpopulations driving disease development, progression, relapse and therapy resistance, and their targeting ensures tumor eradication. CSCs display heterogeneous replication stress (RS), but the functionality/relevance of the RS response (RSR) centered on the ATR-...

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Detalles Bibliográficos
Autores principales: Manic, Gwenola, Musella, Martina, Corradi, Francesca, Sistigu, Antonella, Vitale, Sara, Soliman Abdel Rehim, Sara, Mattiello, Luca, Malacaria, Eva, Galassi, Claudia, Signore, Michele, Pallocca, Matteo, Scalera, Stefano, Goeman, Frauke, De Nicola, Francesca, Guarracino, Andrea, Pennisi, Rosa, Antonangeli, Fabrizio, Sperati, Francesca, Baiocchi, Marta, Biffoni, Mauro, Fanciulli, Maurizio, Maugeri-Saccà, Marcello, Franchitto, Annapaola, Pichierri, Pietro, De Maria, Ruggero, Vitale, Ilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257675/
https://www.ncbi.nlm.nih.gov/pubmed/33531658
http://dx.doi.org/10.1038/s41418-020-00733-4

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