A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts

An ultra-large structure-based virtual screening has discovered iKeap1 as a direct Keap1 inhibitor that can efficiently activate Nrf2 signaling. We here tested its potential effect against hydrogen peroxide (H(2)O(2))-induced oxidative injury in osteoblasts. In primary murine and human osteoblasts,...

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Detalles Bibliográficos
Autores principales: Zheng, Yue-huan, Yang, Jian-jun, Tang, Pei-jun, Zhu, Yuan, Chen, Zhe, She, Chang, Chen, Gang, Cao, Peng, Xu, Xiang-yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257690/
https://www.ncbi.nlm.nih.gov/pubmed/34226516
http://dx.doi.org/10.1038/s41419-021-03962-8

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