The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression

Mutations in the transcription factor C/EBPα are found in ~10% of all acute myeloid leukaemia (AML) cases but the contribution of these mutations to leukemogenesis is incompletely understood. We here use a mouse model of granulocyte progenitors expressing conditionally active HoxB8 to assess the cel...

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Detalles Bibliográficos
Autores principales: Gentle, Ian Edward, Moelter, Isabel, Badr, Mohamed Tarek, Döhner, Konstanze, Lübbert, Michael, Häcker, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257693/
https://www.ncbi.nlm.nih.gov/pubmed/34226527
http://dx.doi.org/10.1038/s41419-021-03948-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257693/
https://www.ncbi.nlm.nih.gov/pubmed/34226527
http://dx.doi.org/10.1038/s41419-021-03948-6

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