Cargando…

The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression

Mutations in the transcription factor C/EBPα are found in ~10% of all acute myeloid leukaemia (AML) cases but the contribution of these mutations to leukemogenesis is incompletely understood. We here use a mouse model of granulocyte progenitors expressing conditionally active HoxB8 to assess the cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gentle, Ian Edward, Moelter, Isabel, Badr, Mohamed Tarek, Döhner, Konstanze, Lübbert, Michael, Häcker, Georg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257693/ https://www.ncbi.nlm.nih.gov/pubmed/34226527 http://dx.doi.org/10.1038/s41419-021-03948-6

Ejemplares similares

Initiation of MLL-rearranged AML is dependent on C/EBPα
por: Ohlsson, Ewa, et al.
Publicado: (2014)

C/EBPα Expression is Partially Regulated by C/EBPβ in Response to DNA Damage and C/EBPα Deficient Fibroblasts Display an Impaired G(1) Checkpoint
por: Ranjan, Rakesh, et al.
Publicado: (2009)

C/EBPα: critical at the origin of leukemic transformation
por: Roe, Jae-Seok, et al.
Publicado: (2014)

C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin
por: House, John S., et al.
Publicado: (2010)

Acetylation of C/EBPα inhibits its granulopoietic function
por: Bararia, Deepak, et al.
Publicado: (2016)

Role of C/EBP-α in Adriamycin-induced podocyte injury
por: Zhong, Fang, et al.
Publicado: (2016)

The Histone Demethylase PHF2 Promotes Fat Cell Differentiation as an Epigenetic Activator of Both C/EBPα and C/EBPδ
por: Lee, Kyoung-Hwa, et al.
Publicado: (2014)

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction
por: Ptasinska, Anetta, et al.
Publicado: (2019)

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction
por: Ptasinska, Anetta, et al.
Publicado: (2019)

How does C/EBPα speed up cell reprogramming?
por: Sardina, Jose Luis, et al.
Publicado: (2016)

A C/EBPα–Wnt connection in gut homeostasis and carcinogenesis
por: Heuberger, Julian, et al.
Publicado: (2018)

Functional roles of C/EBPα and SUMO-modification in lung development
por: Chen, Yuan-Dong, et al.
Publicado: (2017)

C/EBPβ cooperates with MYB to maintain the oncogenic program of AML cells
por: Klempnauer, Karl-Heinz
Publicado: (2023)

A C/ebpα isoform specific differentiation program in immortalized myelocytes
por: Garcia-Cuellar, Maria-Paz, et al.
Publicado: (2023)

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse
por: Bégay, Valérie, et al.
Publicado: (2018)

Shwachman–Bodian–Diamond syndrome (SBDS) protein deficiency impairs translation re-initiation from C/EBPα and C/EBPβ mRNAs
por: In, Kyungmin, et al.
Publicado: (2016)

C/EBPα or C/EBPα oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-κB p50 bound to the bcl-2 and FLIP gene promoters
por: Paz-Priel, I, et al.
Publicado: (2008)

The Circadian Binding of CLOCK Protein to the Promoter of C/ebpα Gene in Mouse Cells
por: Kawasaki, Haruhisa, et al.
Publicado: (2013)

Long Noncoding RNA ADINR Regulates Adipogenesis by Transcriptionally Activating C/EBPα
por: Xiao, Tengfei, et al.
Publicado: (2015)

Dual negative roles of C/EBPα in the expansion and pro-tumor functions of MDSCs
por: Mackert, John R., et al.
Publicado: (2017)

Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα
por: Sridhar, Radhakrishnan, et al.
Publicado: (2018)

Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation
por: Wurm, Alexander Arthur, et al.
Publicado: (2017)

MORC2 regulates C/EBPα-mediated cell differentiation via sumoylation
por: Liu, Jia, et al.
Publicado: (2019)

C/EBPα induces Ebf1 gene expression in common lymphoid progenitors
por: Barberi, Theresa, et al.
Publicado: (2020)

Long noncoding RNA ADINR regulates adipogenesis by transcriptionally activating C/EBPα
por: Xiao, Tengfei, et al.
Publicado: (2021)

Asthma and COPD - The C/EBP Connection
por: Miglino, Nicola, et al.
Publicado: (2012)

Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBPα and PPARα
por: Sun, Ying, et al.
Publicado: (2018)

TNFα Rescues Dendritic Cell Development in Hematopoietic Stem and Progenitor Cells Lacking C/EBPα
por: Anirudh, Subramanian, et al.
Publicado: (2020)

C/EBPβ expression decreases in cervical cancer and leads to tumorigenesis
por: Long, Haichen, et al.
Publicado: (2023)

Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBPα) p42 versus p30 may contribute in part, to aberrant C/EBPα activity in acute leukemias
por: Hankey, William, et al.
Publicado: (2011)

Mutant C/EBPα p30 alleviates immunosuppression of CD8(+) T cells by inhibiting autophagy‐associated secretion of IL‐1β in AML
por: Wang, Jun‐Dan, et al.
Publicado: (2022)

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα
por: Pinto, Jorge P., et al.
Publicado: (2008)

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
por: Grebien, Florian, et al.
Publicado: (2015)

C/EBPα deficiency in podocytes aggravates podocyte senescence and kidney injury in aging mice
por: Zhang, Liwen, et al.
Publicado: (2019)

PPARγ and C/EBPα response to acute cold stress in brown adipose tissue
por: Lau, Kin H., et al.
Publicado: (2022)

Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity
por: Torcal Garcia, Guillem, et al.
Publicado: (2023)

JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
por: Yu, Shan-He, et al.
Publicado: (2018)

Effects of C/EBPα overexpression on alveolar epithelial type II cell proliferation, apoptosis and surfactant protein-C expression after exposure to hyperoxia
por: Lu, Hongyan, et al.
Publicado: (2019)

Centipede grass exerts anti-adipogenic activity through inhibition of C/EBPβ, C/EBPα, and PPARγ expression and the AKT signaling pathway in 3T3-L1 adipocytes
por: Park, Hyoung Joon, et al.
Publicado: (2012)

Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
por: Radomska, Hanna S., et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_2u5ano67580mdb75vprp0hdukl