FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

The protein kinase TBK1 is a central regulator of innate immune responses and autophagy, and ablation of either function has been linked to neuroinflammatory or degenerative diseases. Autophagy is an intracellular process that recycles old or damaged proteins and organelles. In recent years, the TBK...

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Detalles Bibliográficos
Autores principales: Schlütermann, David, Berleth, Niklas, Deitersen, Jana, Wallot-Hieke, Nora, Friesen, Olena, Wu, Wenxian, Stuhldreier, Fabian, Sun, Yadong, Berning, Lena, Friedrich, Annabelle, Mendiburo, María José, Peter, Christoph, Wiek, Constanze, Hanenberg, Helmut, Stefanski, Anja, Stühler, Kai, Stork, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257712/
https://www.ncbi.nlm.nih.gov/pubmed/34226595
http://dx.doi.org/10.1038/s41598-021-92408-4

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