High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct

Growing evidence indicates that prorenin receptor (PRR) is upregulated in collecting duct (CD) of diabetic kidney. Prorenin is secreted by the principal CD cells, and is the natural ligand of the PRR. PRR activation stimulates fibrotic factors, including fibronectin, collagen, and transforming growt...

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Detalles Bibliográficos
Autores principales: Gogulamudi, Venkateswara R., Arita, Danielle Y., Bourgeois, Camille R. T., Jorgensen, Justine, He, Jing, Wimley, William C., Satou, Ryosuke, Gonzalez, Alexis A., Prieto, Minolfa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257763/
https://www.ncbi.nlm.nih.gov/pubmed/34226610
http://dx.doi.org/10.1038/s41598-021-93296-4

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