Current insights into the expression and functions of tumor-derived immunoglobulins

Numerous studies have reported expressions of immunoglobulins (Igs) in many human tumor tissues and cells. Tumor-derived Igs have displayed multiple significant functions which are different from classical Igs produced by B lymphocytes and plasma cells. This review will concentrate on major progress...

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Autores principales: Zhao, Jing, Peng, Hui, Gao, Jie, Nong, Anna, Hua, Haoming, Yang, Shulin, Chen, Liying, Wu, Xiangsheng, Zhang, Hao, Wang, Juping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257790/
https://www.ncbi.nlm.nih.gov/pubmed/34226529
http://dx.doi.org/10.1038/s41420-021-00550-9
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author Zhao, Jing
Peng, Hui
Gao, Jie
Nong, Anna
Hua, Haoming
Yang, Shulin
Chen, Liying
Wu, Xiangsheng
Zhang, Hao
Wang, Juping
author_facet Zhao, Jing
Peng, Hui
Gao, Jie
Nong, Anna
Hua, Haoming
Yang, Shulin
Chen, Liying
Wu, Xiangsheng
Zhang, Hao
Wang, Juping
author_sort Zhao, Jing
collection PubMed
description Numerous studies have reported expressions of immunoglobulins (Igs) in many human tumor tissues and cells. Tumor-derived Igs have displayed multiple significant functions which are different from classical Igs produced by B lymphocytes and plasma cells. This review will concentrate on major progress in expressions, functions, and mechanisms of tumor-derived Igs, similarities and differences between tumor-derived Igs and B-cell-derived Igs. We also discuss the future research directions of tumor-derived Igs, including their structural characteristics, physicochemical properties, mechanisms for rearrangement and expression regulation, signaling pathways involved, and clinical applications.
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spelling pubmed-82577902021-07-23 Current insights into the expression and functions of tumor-derived immunoglobulins Zhao, Jing Peng, Hui Gao, Jie Nong, Anna Hua, Haoming Yang, Shulin Chen, Liying Wu, Xiangsheng Zhang, Hao Wang, Juping Cell Death Discov Review Article Numerous studies have reported expressions of immunoglobulins (Igs) in many human tumor tissues and cells. Tumor-derived Igs have displayed multiple significant functions which are different from classical Igs produced by B lymphocytes and plasma cells. This review will concentrate on major progress in expressions, functions, and mechanisms of tumor-derived Igs, similarities and differences between tumor-derived Igs and B-cell-derived Igs. We also discuss the future research directions of tumor-derived Igs, including their structural characteristics, physicochemical properties, mechanisms for rearrangement and expression regulation, signaling pathways involved, and clinical applications. Nature Publishing Group UK 2021-06-28 /pmc/articles/PMC8257790/ /pubmed/34226529 http://dx.doi.org/10.1038/s41420-021-00550-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Zhao, Jing
Peng, Hui
Gao, Jie
Nong, Anna
Hua, Haoming
Yang, Shulin
Chen, Liying
Wu, Xiangsheng
Zhang, Hao
Wang, Juping
Current insights into the expression and functions of tumor-derived immunoglobulins
title Current insights into the expression and functions of tumor-derived immunoglobulins
title_full Current insights into the expression and functions of tumor-derived immunoglobulins
title_fullStr Current insights into the expression and functions of tumor-derived immunoglobulins
title_full_unstemmed Current insights into the expression and functions of tumor-derived immunoglobulins
title_short Current insights into the expression and functions of tumor-derived immunoglobulins
title_sort current insights into the expression and functions of tumor-derived immunoglobulins
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257790/
https://www.ncbi.nlm.nih.gov/pubmed/34226529
http://dx.doi.org/10.1038/s41420-021-00550-9
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