Endothelial-specific insulin receptor substrate-1 overexpression worsens neonatal hypoxic-ischemic brain injury via mTOR-mediated tight junction disassembly

Hypoxic-ischemic (HI) encephalopathy is the major cause of mortality and disability in newborns. The neurovascular unit is a major target of acute and chronic brain injury, and therapies that protect simultaneously both neurons and vascular endothelial cells from neonatal HI injury are in demand. In...

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Detalles Bibliográficos
Autores principales: Tu, Yi-Fang, Jiang, Si-Tse, Chiang, Chi-Wu, Chen, Li-Ching, Huang, Chao-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257791/
https://www.ncbi.nlm.nih.gov/pubmed/34226528
http://dx.doi.org/10.1038/s41420-021-00548-3

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