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The impact of infection complications after trauma differs according to trauma severity

The impact of infection on the prognosis of trauma patients according to severity remains unclear. We assessed the impact of infection complications on in-hospital mortality among patients with trauma according to severity. This retrospective cohort study used a nationwide registry of trauma patient...

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Autores principales: Komori, Akira, Iriyama, Hiroki, Kainoh, Takako, Aoki, Makoto, Naito, Toshio, Abe, Toshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257796/
https://www.ncbi.nlm.nih.gov/pubmed/34226621
http://dx.doi.org/10.1038/s41598-021-93314-5
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author Komori, Akira
Iriyama, Hiroki
Kainoh, Takako
Aoki, Makoto
Naito, Toshio
Abe, Toshikazu
author_facet Komori, Akira
Iriyama, Hiroki
Kainoh, Takako
Aoki, Makoto
Naito, Toshio
Abe, Toshikazu
author_sort Komori, Akira
collection PubMed
description The impact of infection on the prognosis of trauma patients according to severity remains unclear. We assessed the impact of infection complications on in-hospital mortality among patients with trauma according to severity. This retrospective cohort study used a nationwide registry of trauma patients. Patients aged ≥ 18 years with blunt or penetrating trauma who were admitted to intensive care units or general wards between 2004 and 2017 were included. We compared the baseline characteristics and outcomes between patients with and without infection and conducted a multivariable logistic regression analysis to investigate the impact of infection on in-hospital mortality according to trauma severity, which was classified as mild [Injury Severity Score (ISS) < 15], moderate (ISS 15–29), or severe (ISS ≥ 30). Among the 150,948 patients in this study, 10,338 (6.8%) developed infections. Patients with infection had greater in-hospital mortality than patients without infection [1085 (10.5%) vs. 2898 (2.1%), p < 0.01]. After adjusting for clinical characteristics, in-hospital mortality differed between trauma patients with and without infection according to trauma severity [17.1% (95% CI 15.2–18.9%) vs. 2.9% (95% CI 2.7–3.1%), p < 0.01, in patients with mild trauma; 14.8% (95% CI 13.3–16.3%) vs. 8.4% (95% CI 7.9–8.8%), p < 0.01, in patients with moderate trauma; and 13.5% (95% CI 11.2–15.7%) vs. 13.7% (95% CI 12.4–14.9%), p = 0.86, in patients with severe trauma]. In conclusion, the effect of infection complications in patients with trauma on in-hospital mortality differs by trauma severity.
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spelling pubmed-82577962021-07-08 The impact of infection complications after trauma differs according to trauma severity Komori, Akira Iriyama, Hiroki Kainoh, Takako Aoki, Makoto Naito, Toshio Abe, Toshikazu Sci Rep Article The impact of infection on the prognosis of trauma patients according to severity remains unclear. We assessed the impact of infection complications on in-hospital mortality among patients with trauma according to severity. This retrospective cohort study used a nationwide registry of trauma patients. Patients aged ≥ 18 years with blunt or penetrating trauma who were admitted to intensive care units or general wards between 2004 and 2017 were included. We compared the baseline characteristics and outcomes between patients with and without infection and conducted a multivariable logistic regression analysis to investigate the impact of infection on in-hospital mortality according to trauma severity, which was classified as mild [Injury Severity Score (ISS) < 15], moderate (ISS 15–29), or severe (ISS ≥ 30). Among the 150,948 patients in this study, 10,338 (6.8%) developed infections. Patients with infection had greater in-hospital mortality than patients without infection [1085 (10.5%) vs. 2898 (2.1%), p < 0.01]. After adjusting for clinical characteristics, in-hospital mortality differed between trauma patients with and without infection according to trauma severity [17.1% (95% CI 15.2–18.9%) vs. 2.9% (95% CI 2.7–3.1%), p < 0.01, in patients with mild trauma; 14.8% (95% CI 13.3–16.3%) vs. 8.4% (95% CI 7.9–8.8%), p < 0.01, in patients with moderate trauma; and 13.5% (95% CI 11.2–15.7%) vs. 13.7% (95% CI 12.4–14.9%), p = 0.86, in patients with severe trauma]. In conclusion, the effect of infection complications in patients with trauma on in-hospital mortality differs by trauma severity. Nature Publishing Group UK 2021-07-05 /pmc/articles/PMC8257796/ /pubmed/34226621 http://dx.doi.org/10.1038/s41598-021-93314-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Komori, Akira
Iriyama, Hiroki
Kainoh, Takako
Aoki, Makoto
Naito, Toshio
Abe, Toshikazu
The impact of infection complications after trauma differs according to trauma severity
title The impact of infection complications after trauma differs according to trauma severity
title_full The impact of infection complications after trauma differs according to trauma severity
title_fullStr The impact of infection complications after trauma differs according to trauma severity
title_full_unstemmed The impact of infection complications after trauma differs according to trauma severity
title_short The impact of infection complications after trauma differs according to trauma severity
title_sort impact of infection complications after trauma differs according to trauma severity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257796/
https://www.ncbi.nlm.nih.gov/pubmed/34226621
http://dx.doi.org/10.1038/s41598-021-93314-5
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