WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

Ongoing chronic fibrosis and hypertrophy of the ligamentum flavum (LF) is an important cause of lumbar spinal canal stenosis (LSCS). Our previous work showed that WNT1-inducible signaling pathway protein 1 (WISP-1) is a critical driver of LF fibrosis. However, the potential mechanism has not been ex...

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Detalles Bibliográficos
Autores principales: Sun, Chao, Ma, Qinghong, Yin, Jian, Zhang, Han, Liu, Xinhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257797/
https://www.ncbi.nlm.nih.gov/pubmed/34158608
http://dx.doi.org/10.1038/s12276-021-00636-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257797/
https://www.ncbi.nlm.nih.gov/pubmed/34158608
http://dx.doi.org/10.1038/s12276-021-00636-5

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