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WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

Ongoing chronic fibrosis and hypertrophy of the ligamentum flavum (LF) is an important cause of lumbar spinal canal stenosis (LSCS). Our previous work showed that WNT1-inducible signaling pathway protein 1 (WISP-1) is a critical driver of LF fibrosis. However, the potential mechanism has not been ex...

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Detalles Bibliográficos
Autores principales:	Sun, Chao, Ma, Qinghong, Yin, Jian, Zhang, Han, Liu, Xinhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257797/ https://www.ncbi.nlm.nih.gov/pubmed/34158608 http://dx.doi.org/10.1038/s12276-021-00636-5

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