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Analysis of perinatal coagulation function in preeclampsia

To study the dynamic changes in perinatal coagulation function in patients with preeclampsia (PE). The general data and coagulation indexes of 290 PE patients during the perinatal period (prenatal and 1 and 3 days postpartum) and 256 healthy pregnant women in the third trimester of pregnancy were in...

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Autores principales: Xu, Chang, Li, YunHui, Zhang, Wen, Wang, QiuShi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257867/
https://www.ncbi.nlm.nih.gov/pubmed/34190173
http://dx.doi.org/10.1097/MD.0000000000026482
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author Xu, Chang
Li, YunHui
Zhang, Wen
Wang, QiuShi
author_facet Xu, Chang
Li, YunHui
Zhang, Wen
Wang, QiuShi
author_sort Xu, Chang
collection PubMed
description To study the dynamic changes in perinatal coagulation function in patients with preeclampsia (PE). The general data and coagulation indexes of 290 PE patients during the perinatal period (prenatal and 1 and 3 days postpartum) and 256 healthy pregnant women in the third trimester of pregnancy were investigated, and the data were analyzed. Compared with healthy pregnant women, prothrombin time (PT), fibrinogen (FIB), platelet count (PLT), mean platelet volume (MPV), thrombocytocrit (PCT), maximum amplitude (MA), and coagulation index (CI) of PE patients decreased, and activated partial thrombin time (APTT), thrombin time (TT), D-dimer (DD), platelet distribution width (PDW) and K values increased before delivery (P < .05). APTT and FIB in PE patients were lower in the day 1 postpartum group than in the prenatal and postpartum day 3 groups, and TT, DD, and fibrin degradation products (FDP) were higher (P < .05). PCT and MPV were highest in the prenatal group (P < .05). Compared with that of healthy pregnant women, the coagulation function of PE patients is in a relatively low-coagulation and high-fibrinolysis state on postpartum day 1, which increases the risk of postpartum hemorrhage and other adverse outcomes.
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spelling pubmed-82578672021-07-08 Analysis of perinatal coagulation function in preeclampsia Xu, Chang Li, YunHui Zhang, Wen Wang, QiuShi Medicine (Baltimore) 4800 To study the dynamic changes in perinatal coagulation function in patients with preeclampsia (PE). The general data and coagulation indexes of 290 PE patients during the perinatal period (prenatal and 1 and 3 days postpartum) and 256 healthy pregnant women in the third trimester of pregnancy were investigated, and the data were analyzed. Compared with healthy pregnant women, prothrombin time (PT), fibrinogen (FIB), platelet count (PLT), mean platelet volume (MPV), thrombocytocrit (PCT), maximum amplitude (MA), and coagulation index (CI) of PE patients decreased, and activated partial thrombin time (APTT), thrombin time (TT), D-dimer (DD), platelet distribution width (PDW) and K values increased before delivery (P < .05). APTT and FIB in PE patients were lower in the day 1 postpartum group than in the prenatal and postpartum day 3 groups, and TT, DD, and fibrin degradation products (FDP) were higher (P < .05). PCT and MPV were highest in the prenatal group (P < .05). Compared with that of healthy pregnant women, the coagulation function of PE patients is in a relatively low-coagulation and high-fibrinolysis state on postpartum day 1, which increases the risk of postpartum hemorrhage and other adverse outcomes. Lippincott Williams & Wilkins 2021-07-02 /pmc/articles/PMC8257867/ /pubmed/34190173 http://dx.doi.org/10.1097/MD.0000000000026482 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 4800
Xu, Chang
Li, YunHui
Zhang, Wen
Wang, QiuShi
Analysis of perinatal coagulation function in preeclampsia
title Analysis of perinatal coagulation function in preeclampsia
title_full Analysis of perinatal coagulation function in preeclampsia
title_fullStr Analysis of perinatal coagulation function in preeclampsia
title_full_unstemmed Analysis of perinatal coagulation function in preeclampsia
title_short Analysis of perinatal coagulation function in preeclampsia
title_sort analysis of perinatal coagulation function in preeclampsia
topic 4800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257867/
https://www.ncbi.nlm.nih.gov/pubmed/34190173
http://dx.doi.org/10.1097/MD.0000000000026482
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