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Mucormycosis: An opportunistic pathogen during COVID-19

The pandemic of coronavirus disease 2019 (COVID-19) still remains on an upsurge trend. The second wave of this disease has led to panic in many countries, including India and some parts of the world suffering from the third wave. As there are no proper treatment options or remedies available for thi...

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Autores principales: Mahalaxmi, Iyer, Jayaramayya, Kaavya, Venkatesan, Dhivya, Subramaniam, Mohana Devi, Renu, Kaviyarasi, Vijayakumar, Padmavathi, Narayanasamy, Arul, Gopalakrishnan, Abilash Valsala, Kumar, Nachimuthu Senthil, Sivaprakash, Palanisamy, Sambasiva Rao, Krothapalli R.S., Vellingiri, Balachandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258024/
https://www.ncbi.nlm.nih.gov/pubmed/34237335
http://dx.doi.org/10.1016/j.envres.2021.111643
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author Mahalaxmi, Iyer
Jayaramayya, Kaavya
Venkatesan, Dhivya
Subramaniam, Mohana Devi
Renu, Kaviyarasi
Vijayakumar, Padmavathi
Narayanasamy, Arul
Gopalakrishnan, Abilash Valsala
Kumar, Nachimuthu Senthil
Sivaprakash, Palanisamy
Sambasiva Rao, Krothapalli R.S.
Vellingiri, Balachandar
author_facet Mahalaxmi, Iyer
Jayaramayya, Kaavya
Venkatesan, Dhivya
Subramaniam, Mohana Devi
Renu, Kaviyarasi
Vijayakumar, Padmavathi
Narayanasamy, Arul
Gopalakrishnan, Abilash Valsala
Kumar, Nachimuthu Senthil
Sivaprakash, Palanisamy
Sambasiva Rao, Krothapalli R.S.
Vellingiri, Balachandar
author_sort Mahalaxmi, Iyer
collection PubMed
description The pandemic of coronavirus disease 2019 (COVID-19) still remains on an upsurge trend. The second wave of this disease has led to panic in many countries, including India and some parts of the world suffering from the third wave. As there are no proper treatment options or remedies available for this deadly infection, supportive care equipment's such as oxygen cylinders, ventilators and heavy use of steroids play a vital role in the management of COVID-19. In the midst of this pandemic, the COVID-19 patients are acquiring secondary infections such as mucormycosis also known as black fungus disease. Mucormycosis is a serious, but rare opportunistic fungal infection that spreads rapidly, and hence prompt diagnosis and treatment are necessary to avoid high rate of mortality and morbidity rates. Mucormycosis is caused by the inhalation of its filamentous (hyphal form) fungi especially in the patients who are immunosuppressed. Recent studies have documented alarming number of COVID-19 patients with mucormycosis infection. Most of these patients had diabetes and were administered steroids for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and were consequently more prone to mucormycosis. Hence, the present review emphasizes mucormycosis and its related conditions, its mechanism in normal and COVID-19 affected individuals, influencing factors and challenges to overcome this black mold infection. Early identification and further investigation of this fungus will significantly reduce the severity of the disease and mortality rate in COVID-19 affected patients.
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spelling pubmed-82580242021-07-06 Mucormycosis: An opportunistic pathogen during COVID-19 Mahalaxmi, Iyer Jayaramayya, Kaavya Venkatesan, Dhivya Subramaniam, Mohana Devi Renu, Kaviyarasi Vijayakumar, Padmavathi Narayanasamy, Arul Gopalakrishnan, Abilash Valsala Kumar, Nachimuthu Senthil Sivaprakash, Palanisamy Sambasiva Rao, Krothapalli R.S. Vellingiri, Balachandar Environ Res Article The pandemic of coronavirus disease 2019 (COVID-19) still remains on an upsurge trend. The second wave of this disease has led to panic in many countries, including India and some parts of the world suffering from the third wave. As there are no proper treatment options or remedies available for this deadly infection, supportive care equipment's such as oxygen cylinders, ventilators and heavy use of steroids play a vital role in the management of COVID-19. In the midst of this pandemic, the COVID-19 patients are acquiring secondary infections such as mucormycosis also known as black fungus disease. Mucormycosis is a serious, but rare opportunistic fungal infection that spreads rapidly, and hence prompt diagnosis and treatment are necessary to avoid high rate of mortality and morbidity rates. Mucormycosis is caused by the inhalation of its filamentous (hyphal form) fungi especially in the patients who are immunosuppressed. Recent studies have documented alarming number of COVID-19 patients with mucormycosis infection. Most of these patients had diabetes and were administered steroids for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and were consequently more prone to mucormycosis. Hence, the present review emphasizes mucormycosis and its related conditions, its mechanism in normal and COVID-19 affected individuals, influencing factors and challenges to overcome this black mold infection. Early identification and further investigation of this fungus will significantly reduce the severity of the disease and mortality rate in COVID-19 affected patients. Elsevier Inc. 2021-10 2021-07-06 /pmc/articles/PMC8258024/ /pubmed/34237335 http://dx.doi.org/10.1016/j.envres.2021.111643 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mahalaxmi, Iyer
Jayaramayya, Kaavya
Venkatesan, Dhivya
Subramaniam, Mohana Devi
Renu, Kaviyarasi
Vijayakumar, Padmavathi
Narayanasamy, Arul
Gopalakrishnan, Abilash Valsala
Kumar, Nachimuthu Senthil
Sivaprakash, Palanisamy
Sambasiva Rao, Krothapalli R.S.
Vellingiri, Balachandar
Mucormycosis: An opportunistic pathogen during COVID-19
title Mucormycosis: An opportunistic pathogen during COVID-19
title_full Mucormycosis: An opportunistic pathogen during COVID-19
title_fullStr Mucormycosis: An opportunistic pathogen during COVID-19
title_full_unstemmed Mucormycosis: An opportunistic pathogen during COVID-19
title_short Mucormycosis: An opportunistic pathogen during COVID-19
title_sort mucormycosis: an opportunistic pathogen during covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258024/
https://www.ncbi.nlm.nih.gov/pubmed/34237335
http://dx.doi.org/10.1016/j.envres.2021.111643
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