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Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells

The mesenchymal stem cells have multidirectional differentiation potential and can differentiate into adipocytes, osteoblasts, cartilage tissue, muscle cells and so on. The adipogenic differentiation of mesenchymal stem cells is of great significance for the construction of tissue-engineered fat and...

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Autores principales: Zhong, Yuxuan, Li, Xiang, Wang, Fanglin, Wang, Shoushuai, Wang, Xiaohong, Tian, Xiaohong, Bai, Shuling, Miao, Di, Fan, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258133/
https://www.ncbi.nlm.nih.gov/pubmed/34239869
http://dx.doi.org/10.3389/fcell.2021.649552
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author Zhong, Yuxuan
Li, Xiang
Wang, Fanglin
Wang, Shoushuai
Wang, Xiaohong
Tian, Xiaohong
Bai, Shuling
Miao, Di
Fan, Jun
author_facet Zhong, Yuxuan
Li, Xiang
Wang, Fanglin
Wang, Shoushuai
Wang, Xiaohong
Tian, Xiaohong
Bai, Shuling
Miao, Di
Fan, Jun
author_sort Zhong, Yuxuan
collection PubMed
description The mesenchymal stem cells have multidirectional differentiation potential and can differentiate into adipocytes, osteoblasts, cartilage tissue, muscle cells and so on. The adipogenic differentiation of mesenchymal stem cells is of great significance for the construction of tissue-engineered fat and the treatment of soft tissue defects. Exosomes are nanoscale vesicles secreted by cells and widely exist in body fluids. They are mainly involved in cell communication processes and transferring cargo contents to recipient cells. In addition, exosomes can also promote tissue and organ regeneration. Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. In this review, the effects of exosomes on stem cell differentiation, especially on adipogenic differentiation, will be discussed, and the mechanisms and conclusions will be drawn. The main purpose of studying the role of these exosomes is to understand more comprehensively the influencing factors existing in the process of stem cell differentiation into adipocytes and provide a new idea in adipose tissue engineering research.
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spelling pubmed-82581332021-07-07 Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells Zhong, Yuxuan Li, Xiang Wang, Fanglin Wang, Shoushuai Wang, Xiaohong Tian, Xiaohong Bai, Shuling Miao, Di Fan, Jun Front Cell Dev Biol Cell and Developmental Biology The mesenchymal stem cells have multidirectional differentiation potential and can differentiate into adipocytes, osteoblasts, cartilage tissue, muscle cells and so on. The adipogenic differentiation of mesenchymal stem cells is of great significance for the construction of tissue-engineered fat and the treatment of soft tissue defects. Exosomes are nanoscale vesicles secreted by cells and widely exist in body fluids. They are mainly involved in cell communication processes and transferring cargo contents to recipient cells. In addition, exosomes can also promote tissue and organ regeneration. Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. In this review, the effects of exosomes on stem cell differentiation, especially on adipogenic differentiation, will be discussed, and the mechanisms and conclusions will be drawn. The main purpose of studying the role of these exosomes is to understand more comprehensively the influencing factors existing in the process of stem cell differentiation into adipocytes and provide a new idea in adipose tissue engineering research. Frontiers Media S.A. 2021-06-22 /pmc/articles/PMC8258133/ /pubmed/34239869 http://dx.doi.org/10.3389/fcell.2021.649552 Text en Copyright © 2021 Zhong, Li, Wang, Wang, Wang, Tian, Bai, Miao and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhong, Yuxuan
Li, Xiang
Wang, Fanglin
Wang, Shoushuai
Wang, Xiaohong
Tian, Xiaohong
Bai, Shuling
Miao, Di
Fan, Jun
Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells
title Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells
title_full Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells
title_fullStr Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells
title_full_unstemmed Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells
title_short Emerging Potential of Exosomes on Adipogenic Differentiation of Mesenchymal Stem Cells
title_sort emerging potential of exosomes on adipogenic differentiation of mesenchymal stem cells
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258133/
https://www.ncbi.nlm.nih.gov/pubmed/34239869
http://dx.doi.org/10.3389/fcell.2021.649552
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