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The P2X7 Receptor in Tumor Immunity

Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space increases dramatically during tissue damage and eATP acts as a danger-associated molecular pattern (DAMP) to alert innate i...

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Autores principales: Grassi, Fabio, De Ponte Conti, Benedetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258391/
https://www.ncbi.nlm.nih.gov/pubmed/34239877
http://dx.doi.org/10.3389/fcell.2021.694831
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author Grassi, Fabio
De Ponte Conti, Benedetta
author_facet Grassi, Fabio
De Ponte Conti, Benedetta
author_sort Grassi, Fabio
collection PubMed
description Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space increases dramatically during tissue damage and eATP acts as a danger-associated molecular pattern (DAMP) to alert innate immune system cells for tissue repair. Similarly, eATP is present at hundreds of micromolar concentration in the tumor microenvironment (TME). However, its impact on antitumor immune response is still not well established, probably because of the complexity of the responses it induces in different cells constituting the TME. On one hand, ATP released by tumor cells concomitantly to cell death can contribute to immunogenic cell death (ICD) that is proinflammatory for the innate immune compartment and beneficial for tumor control, while on the other hand, eATP can foster immune-suppressive mechanisms within the TME, thus contributing to tumor progression and metastasis. It is well established that T-cell immunity is pivotal in limiting tumor growth and possibly eradicating neoplastic cells. T cells are limited though in their antitumor activity through different mechanisms, such as exhaustion, anergy, and senescence; the pathways resulting in these cellular outcomes are not clear. Here, we review the function of P2X7 receptor in conditioning T cell-dependent immunity against cancer.
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spelling pubmed-82583912021-07-07 The P2X7 Receptor in Tumor Immunity Grassi, Fabio De Ponte Conti, Benedetta Front Cell Dev Biol Cell and Developmental Biology Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space increases dramatically during tissue damage and eATP acts as a danger-associated molecular pattern (DAMP) to alert innate immune system cells for tissue repair. Similarly, eATP is present at hundreds of micromolar concentration in the tumor microenvironment (TME). However, its impact on antitumor immune response is still not well established, probably because of the complexity of the responses it induces in different cells constituting the TME. On one hand, ATP released by tumor cells concomitantly to cell death can contribute to immunogenic cell death (ICD) that is proinflammatory for the innate immune compartment and beneficial for tumor control, while on the other hand, eATP can foster immune-suppressive mechanisms within the TME, thus contributing to tumor progression and metastasis. It is well established that T-cell immunity is pivotal in limiting tumor growth and possibly eradicating neoplastic cells. T cells are limited though in their antitumor activity through different mechanisms, such as exhaustion, anergy, and senescence; the pathways resulting in these cellular outcomes are not clear. Here, we review the function of P2X7 receptor in conditioning T cell-dependent immunity against cancer. Frontiers Media S.A. 2021-06-22 /pmc/articles/PMC8258391/ /pubmed/34239877 http://dx.doi.org/10.3389/fcell.2021.694831 Text en Copyright © 2021 Grassi and De Ponte Conti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Grassi, Fabio
De Ponte Conti, Benedetta
The P2X7 Receptor in Tumor Immunity
title The P2X7 Receptor in Tumor Immunity
title_full The P2X7 Receptor in Tumor Immunity
title_fullStr The P2X7 Receptor in Tumor Immunity
title_full_unstemmed The P2X7 Receptor in Tumor Immunity
title_short The P2X7 Receptor in Tumor Immunity
title_sort p2x7 receptor in tumor immunity
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258391/
https://www.ncbi.nlm.nih.gov/pubmed/34239877
http://dx.doi.org/10.3389/fcell.2021.694831
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