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Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe
Pyramidal neurons are the most abundant and characteristic neuronal type in the cerebral cortex and their dendritic spines are the main postsynaptic elements of cortical excitatory synapses. Previous studies have shown that pyramidal cell structure differs across layers, cortical areas, and species....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258433/ https://www.ncbi.nlm.nih.gov/pubmed/33723567 http://dx.doi.org/10.1093/cercor/bhab034 |
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author | Benavides-Piccione, Ruth Rojo, Concepcion Kastanauskaite, Asta DeFelipe, Javier |
author_facet | Benavides-Piccione, Ruth Rojo, Concepcion Kastanauskaite, Asta DeFelipe, Javier |
author_sort | Benavides-Piccione, Ruth |
collection | PubMed |
description | Pyramidal neurons are the most abundant and characteristic neuronal type in the cerebral cortex and their dendritic spines are the main postsynaptic elements of cortical excitatory synapses. Previous studies have shown that pyramidal cell structure differs across layers, cortical areas, and species. However, within the human cortex, the pyramidal dendritic morphology has been quantified in detail in relatively few cortical areas. In the present work, we performed intracellular injections of Lucifer Yellow at several distances from the temporal pole. We found regional differences in pyramidal cell morphology, which showed large inter-individual variability in most of the morphological variables measured. However, some values remained similar in all cases. The smallest and least complex cells in the most posterior temporal region showed the greatest dendritic spine density. Neurons in the temporal pole showed the greatest sizes with the highest number of spines. Layer V cells were larger, more complex, and had a greater number of dendritic spines than those in layer III. The present results suggest that, while some aspects of pyramidal structure are conserved, there are specific variations across cortical regions, and species. |
format | Online Article Text |
id | pubmed-8258433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82584332021-07-07 Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe Benavides-Piccione, Ruth Rojo, Concepcion Kastanauskaite, Asta DeFelipe, Javier Cereb Cortex Original Article Pyramidal neurons are the most abundant and characteristic neuronal type in the cerebral cortex and their dendritic spines are the main postsynaptic elements of cortical excitatory synapses. Previous studies have shown that pyramidal cell structure differs across layers, cortical areas, and species. However, within the human cortex, the pyramidal dendritic morphology has been quantified in detail in relatively few cortical areas. In the present work, we performed intracellular injections of Lucifer Yellow at several distances from the temporal pole. We found regional differences in pyramidal cell morphology, which showed large inter-individual variability in most of the morphological variables measured. However, some values remained similar in all cases. The smallest and least complex cells in the most posterior temporal region showed the greatest dendritic spine density. Neurons in the temporal pole showed the greatest sizes with the highest number of spines. Layer V cells were larger, more complex, and had a greater number of dendritic spines than those in layer III. The present results suggest that, while some aspects of pyramidal structure are conserved, there are specific variations across cortical regions, and species. Oxford University Press 2021-03-16 /pmc/articles/PMC8258433/ /pubmed/33723567 http://dx.doi.org/10.1093/cercor/bhab034 Text en © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Article Benavides-Piccione, Ruth Rojo, Concepcion Kastanauskaite, Asta DeFelipe, Javier Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe |
title | Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe |
title_full | Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe |
title_fullStr | Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe |
title_full_unstemmed | Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe |
title_short | Variation in Pyramidal Cell Morphology Across the Human Anterior Temporal Lobe |
title_sort | variation in pyramidal cell morphology across the human anterior temporal lobe |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258433/ https://www.ncbi.nlm.nih.gov/pubmed/33723567 http://dx.doi.org/10.1093/cercor/bhab034 |
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