High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing intestinal stem cell (ISC) numbers, proliferation, and function. Although PPAR (peroxisome proliferator-activated recep...

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Detalles Bibliográficos
Autores principales: Mana, Miyeko D., Hussey, Amanda M., Tzouanas, Constantine N., Imada, Shinya, Millan, Yesenia Barrera, Bahceci, Dorukhan, Saiz, Dominic R., Webb, Anna T., Lewis, Caroline A., Carmeliet, Peter, Mihaylova, Maria M., Shalek, Alex K., Yilmaz, Ömer H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258630/
https://www.ncbi.nlm.nih.gov/pubmed/34107251
http://dx.doi.org/10.1016/j.celrep.2021.109212

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