Cargando…

Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ

Nuclear receptors (NRs) activate transcription of target genes in response to binding of ligands to their ligand-binding domains (LBDs). Typically, in vitro assays use either gene expression or the recruitment of coactivators to the isolated LBD of the NR of interest to measure NR activation. Howeve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kilu, Whitney, Merk, Daniel, Steinhilber, Dieter, Proschak, Ewgenij, Heering, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258697/ https://www.ncbi.nlm.nih.gov/pubmed/34081964 http://dx.doi.org/10.1016/j.jbc.2021.100814

Ejemplares similares

Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro
por: Heitel, Pascal, et al.
Publicado: (2018)

Systematic Assessment of Fragment Identification for Multitarget Drug Design
por: Brunst, Steffen, et al.
Publicado: (2021)

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ
por: Göbel, Tamara, et al.
Publicado: (2019)

Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator–Activated Receptor γ (Pparγ) Heterodimer: A Basis for New Therapeutic Strategies
por: Desreumaux, Pierre, et al.
Publicado: (2001)

Examination of Ligand-Dependent Coactivator Recruitment by Peroxisome Proliferator-Activated Receptor-α (PPARα)
por: Tien, Eric S., et al.
Publicado: (2006)

Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms
por: Chaikuad, Apirat, et al.
Publicado: (2020)

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
por: Kojetin, Douglas J., et al.
Publicado: (2015)

Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
por: Lizcano, Fernando, et al.
Publicado: (2013)

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
por: le Maire, Albane, et al.
Publicado: (2019)

Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex
por: Ricci, Clarisse G., et al.
Publicado: (2016)

T-Cell Death-Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis
por: Kim, Sumi, et al.
Publicado: (2021)

Peroxisome Proliferator-Activated Receptor α (PPARα) down-regulation in cystic fibrosis lymphocytes
por: Reynders, Veerle, et al.
Publicado: (2006)

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation
por: Arifi, Silvia, et al.
Publicado: (2023)

Correlation of Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) and Retinoid X Receptor-α (RXR-α) expression with clinical risk factors in patients with advanced carotid atherosclerosis
por: Giaginis, Constantinos, et al.
Publicado: (2011)

The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs
por: Willems, Sabine, et al.
Publicado: (2020)

Development and in vitro Profiling of Dual FXR/LTA4H Modulators
por: Schierle, Simone, et al.
Publicado: (2021)

Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries
por: Willems, Sabine, et al.
Publicado: (2022)

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations
por: Fulton, Joel, et al.
Publicado: (2017)

RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury
por: van Neerven, Sabien, et al.
Publicado: (2007)

The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages
por: Daniel, Bence, et al.
Publicado: (2018)

NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor
por: Schmidt, Jurema, et al.
Publicado: (2015)

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR–RXR
por: Osz, Judit, et al.
Publicado: (2020)

Microsecond MD Simulations to Explore the Structural and Energetic Differences between the Human RXRα-PPARγ vs. RXRα-PPARγ-DNA
por: Azam, Faizul, et al.
Publicado: (2022)

Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex
por: Lemkul, Justin A., et al.
Publicado: (2015)

Solution Structures of PPARγ2/RXRα Complexes
por: Osz, Judit, et al.
Publicado: (2012)

The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor
por: Parshina, Elena A., et al.
Publicado: (2022)

Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha
por: Conde, Isabel, et al.
Publicado: (2008)

Activity Screening of Fatty Acid Mimetic Drugs Identified Nuclear Receptor Agonists
por: Helmstädter, Moritz, et al.
Publicado: (2022)

Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer
por: Belorusova, Anna Y, et al.
Publicado: (2020)

Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures
por: Delfosse, Vanessa, et al.
Publicado: (2021)

Steatosis and Metabolic Disorders Associated with Synergistic Activation of the CAR/RXR Heterodimer by Pesticides
por: Dauwe, Yannick, et al.
Publicado: (2023)

SAT006 Activation Of The CAR/RXR Heterodimer By Pesticides And Induced Metabolic Effects
por: Dauwe, Yannick, et al.
Publicado: (2023)

Molecular Determinants of Magnolol Targeting Both RXRα and PPARγ
por: Zhang, Haitao, et al.
Publicado: (2011)

Underexpression of peroxisome proliferator-activated receptor (PPAR)γ in PAX8/PPARγ-negative thyroid tumours
por: Marques, A R, et al.
Publicado: (2004)

Expression of peroxisome proliferator-activated receptor (PPAR)γ in gastric cancer and inhibitory effects of PPARγ agonists
por: Sato, H, et al.
Publicado: (2000)

The role of peroxisome proliferator-activated receptor-coactivator-1 gene in skin aging
por: Aghaei, Shahrzad, et al.
Publicado: (2016)

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex
por: Zhang, Jun, et al.
Publicado: (2011)

Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease
por: Mello, Tommaso, et al.
Publicado: (2009)

Oleamide activates peroxisome proliferator-activated receptor gamma (PPARγ) in vitro
por: Alexander, Stephen PH, et al.
Publicado: (2012)

Functions of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Gynecologic Disorders
por: Ren, Ping, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1gd9pejeh1mvj6pd86egn1kru8