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Péptido natriurético cerebral tipo B como marcador de sobrecarga hemodinámica del conducto arterioso permeable en el recién nacido prematuro
INTRODUCTION: The echocardiogram is the gold standard, in the diagnosis of the hemodynamically significant patent ductus arteriosus (hs-PDA) of the premature newborn (PNB). Type B natriuretic peptide (BNP) may be useful in the diagnosis and management of CAP-hs. OBJECTIVE: To assess the utility of B...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Permanyer Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258918/ https://www.ncbi.nlm.nih.gov/pubmed/33142312 http://dx.doi.org/10.24875/ACM.19000398 |
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author | Parra-Bravo, J. Rafael Valdovinos-Ponce, M. Teresa García, Heladia Núñez-Enríquez, Juan C. Jiménez-Cárdenas, M. Lourdes Avilés-Monjaraz, Rodrigo Lavana-Hernández, Wendy |
author_facet | Parra-Bravo, J. Rafael Valdovinos-Ponce, M. Teresa García, Heladia Núñez-Enríquez, Juan C. Jiménez-Cárdenas, M. Lourdes Avilés-Monjaraz, Rodrigo Lavana-Hernández, Wendy |
author_sort | Parra-Bravo, J. Rafael |
collection | PubMed |
description | INTRODUCTION: The echocardiogram is the gold standard, in the diagnosis of the hemodynamically significant patent ductus arteriosus (hs-PDA) of the premature newborn (PNB). Type B natriuretic peptide (BNP) may be useful in the diagnosis and management of CAP-hs. OBJECTIVE: To assess the utility of BNP as a marker of hemodynamic overload of the patent ductus arteriosus in newborns with gestational age < 32 weeks or weight < 1500 grams, and to identify the best cut-off point for BNP levels that would best predict a PDA with hemodynamic impact requiring pharmacological and/or surgical treatment. METHODS: Retrospective, observational and descriptive study of PNB < 32 weeks gestation or weight < 1500 grams, in which echocardiogram and BNP determination was performed. Analysis of the global sample and by subgroups, depending on the hs-PDA status was performed. RESULTS: A total of 29 patients were analyzed. A significant correlation was found between the PDA/weight ratio and BNP levels (Spearman: 0.71; 95% confidence interval: 0.45-0.87; p < 0.001). The best BNP cut-off point to predict CAP-hs was 486.5 pg/ml with a sensitivity of 81% and specificity of 92% (p < 0.001). CONCLUSION: The BNP cut-off point identified in the present study was correlated with the presence of CAP-hs. |
format | Online Article Text |
id | pubmed-8258918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Permanyer Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-82589182021-07-15 Péptido natriurético cerebral tipo B como marcador de sobrecarga hemodinámica del conducto arterioso permeable en el recién nacido prematuro Parra-Bravo, J. Rafael Valdovinos-Ponce, M. Teresa García, Heladia Núñez-Enríquez, Juan C. Jiménez-Cárdenas, M. Lourdes Avilés-Monjaraz, Rodrigo Lavana-Hernández, Wendy Arch Cardiol Mex Artículo De Investigación INTRODUCTION: The echocardiogram is the gold standard, in the diagnosis of the hemodynamically significant patent ductus arteriosus (hs-PDA) of the premature newborn (PNB). Type B natriuretic peptide (BNP) may be useful in the diagnosis and management of CAP-hs. OBJECTIVE: To assess the utility of BNP as a marker of hemodynamic overload of the patent ductus arteriosus in newborns with gestational age < 32 weeks or weight < 1500 grams, and to identify the best cut-off point for BNP levels that would best predict a PDA with hemodynamic impact requiring pharmacological and/or surgical treatment. METHODS: Retrospective, observational and descriptive study of PNB < 32 weeks gestation or weight < 1500 grams, in which echocardiogram and BNP determination was performed. Analysis of the global sample and by subgroups, depending on the hs-PDA status was performed. RESULTS: A total of 29 patients were analyzed. A significant correlation was found between the PDA/weight ratio and BNP levels (Spearman: 0.71; 95% confidence interval: 0.45-0.87; p < 0.001). The best BNP cut-off point to predict CAP-hs was 486.5 pg/ml with a sensitivity of 81% and specificity of 92% (p < 0.001). CONCLUSION: The BNP cut-off point identified in the present study was correlated with the presence of CAP-hs. Permanyer Publications 2021 2020-11-03 /pmc/articles/PMC8258918/ /pubmed/33142312 http://dx.doi.org/10.24875/ACM.19000398 Text en Copyright: © 2021 Permanyer https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Artículo De Investigación Parra-Bravo, J. Rafael Valdovinos-Ponce, M. Teresa García, Heladia Núñez-Enríquez, Juan C. Jiménez-Cárdenas, M. Lourdes Avilés-Monjaraz, Rodrigo Lavana-Hernández, Wendy Péptido natriurético cerebral tipo B como marcador de sobrecarga hemodinámica del conducto arterioso permeable en el recién nacido prematuro |
title | Péptido natriurético cerebral tipo B como marcador de sobrecarga hemodinámica del conducto arterioso permeable en el recién nacido prematuro |
title_full | Péptido natriurético cerebral tipo B como marcador de sobrecarga hemodinámica del conducto arterioso permeable en el recién nacido prematuro |
title_fullStr | Péptido natriurético cerebral tipo B como marcador de sobrecarga hemodinámica del conducto arterioso permeable en el recién nacido prematuro |
title_full_unstemmed | Péptido natriurético cerebral tipo B como marcador de sobrecarga hemodinámica del conducto arterioso permeable en el recién nacido prematuro |
title_short | Péptido natriurético cerebral tipo B como marcador de sobrecarga hemodinámica del conducto arterioso permeable en el recién nacido prematuro |
title_sort | péptido natriurético cerebral tipo b como marcador de sobrecarga hemodinámica del conducto arterioso permeable en el recién nacido prematuro |
topic | Artículo De Investigación |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258918/ https://www.ncbi.nlm.nih.gov/pubmed/33142312 http://dx.doi.org/10.24875/ACM.19000398 |
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