Cargando…

Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia

BACKGROUND: A better comprehension of the redox status during the periparturient period may facilitate the development of management and nutritional solutions to prevent subclinical hyperketonemia (SCHK) and subclinical hypocalcemia (SCHC) in dairy goats. We aimed to evaluate the variation in the re...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Yan, Wen, Jing, Kong, Yezi, Zhao, Chenxu, Liu, Siqi, Liu, Yaoquan, Li, Lan, Yang, Jiaqi, Zhu, Xiaoyan, Zhao, Baoyu, Cao, Binyun, Wang, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258950/
https://www.ncbi.nlm.nih.gov/pubmed/34229683
http://dx.doi.org/10.1186/s12917-021-02947-1
_version_ 1783718588853518336
author Huang, Yan
Wen, Jing
Kong, Yezi
Zhao, Chenxu
Liu, Siqi
Liu, Yaoquan
Li, Lan
Yang, Jiaqi
Zhu, Xiaoyan
Zhao, Baoyu
Cao, Binyun
Wang, Jianguo
author_facet Huang, Yan
Wen, Jing
Kong, Yezi
Zhao, Chenxu
Liu, Siqi
Liu, Yaoquan
Li, Lan
Yang, Jiaqi
Zhu, Xiaoyan
Zhao, Baoyu
Cao, Binyun
Wang, Jianguo
author_sort Huang, Yan
collection PubMed
description BACKGROUND: A better comprehension of the redox status during the periparturient period may facilitate the development of management and nutritional solutions to prevent subclinical hyperketonemia (SCHK) and subclinical hypocalcemia (SCHC) in dairy goats. We aimed to evaluate the variation in the redox status of dairy goats with SCHK and SCHC during their periparturient periods. Guanzhong dairy goats (n = 30) were assigned to SCHK (n = 10), SCHC (n = 10), and healthy (HEAL, n = 10) groups based on their blood β-hydroxybutyrate (BHBA) and calcium (Ca) concentrations. Blood were withdrawn from goats every week from 3 weeks before the expected parturition date to 3 weeks post-kidding. On the same day, the body condition scores (BCS) were evaluated, and the milk yield was recorded for each goat. The metabolic profile parameters and the indicators of oxidative status were determined by using the standard biochemical techniques. RESULTS: In comparison with the HEAL goats, SCHK and SCHC goats presented with a more dramatic decline of BCS post-kidding and a significant decrease in the milk yield at 2- and 3-weeks postpartum, ignoring the obvious increase at 1-week postpartum. The levels of non-esterified fatty acids (NEFA) peaked at parturition, exhibiting significantly higher levels from 1-week prepartum to the parturition day in the SCHK and SCHC groups. The malondialdehyde (MDA) concentration was increased in the SCHK goats from 1-week antepartum until 3-weeks postpartum, with its concentration being significantly higher in the SCHC goats at parturition. The hydrogen peroxide (H(2)O(2)) concentration was significantly lower in the SCHK and SCHC goats from 2-weeks antepartum to 1-week post-kidding. The total antioxidant capacity (T-AOC) and the superoxide dismutase (SOD) level were decreased at 1-week antepartum in the SCHK and SCHC goats, respectively. The glutathione peroxidase (GSH-Px) level was increased in the SCHK and SCHC goats during the early lactation period. CONCLUSIONS: The SCHK and SCHC goats exerted more efforts to maintain their redox homeostasis and to ensure the production performance than the HEAL goats during their periparturient period, probably owing to more intense fat mobilization and lipid peroxidation in the former.
format Online
Article
Text
id pubmed-8258950
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-82589502021-07-06 Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia Huang, Yan Wen, Jing Kong, Yezi Zhao, Chenxu Liu, Siqi Liu, Yaoquan Li, Lan Yang, Jiaqi Zhu, Xiaoyan Zhao, Baoyu Cao, Binyun Wang, Jianguo BMC Vet Res Research Article BACKGROUND: A better comprehension of the redox status during the periparturient period may facilitate the development of management and nutritional solutions to prevent subclinical hyperketonemia (SCHK) and subclinical hypocalcemia (SCHC) in dairy goats. We aimed to evaluate the variation in the redox status of dairy goats with SCHK and SCHC during their periparturient periods. Guanzhong dairy goats (n = 30) were assigned to SCHK (n = 10), SCHC (n = 10), and healthy (HEAL, n = 10) groups based on their blood β-hydroxybutyrate (BHBA) and calcium (Ca) concentrations. Blood were withdrawn from goats every week from 3 weeks before the expected parturition date to 3 weeks post-kidding. On the same day, the body condition scores (BCS) were evaluated, and the milk yield was recorded for each goat. The metabolic profile parameters and the indicators of oxidative status were determined by using the standard biochemical techniques. RESULTS: In comparison with the HEAL goats, SCHK and SCHC goats presented with a more dramatic decline of BCS post-kidding and a significant decrease in the milk yield at 2- and 3-weeks postpartum, ignoring the obvious increase at 1-week postpartum. The levels of non-esterified fatty acids (NEFA) peaked at parturition, exhibiting significantly higher levels from 1-week prepartum to the parturition day in the SCHK and SCHC groups. The malondialdehyde (MDA) concentration was increased in the SCHK goats from 1-week antepartum until 3-weeks postpartum, with its concentration being significantly higher in the SCHC goats at parturition. The hydrogen peroxide (H(2)O(2)) concentration was significantly lower in the SCHK and SCHC goats from 2-weeks antepartum to 1-week post-kidding. The total antioxidant capacity (T-AOC) and the superoxide dismutase (SOD) level were decreased at 1-week antepartum in the SCHK and SCHC goats, respectively. The glutathione peroxidase (GSH-Px) level was increased in the SCHK and SCHC goats during the early lactation period. CONCLUSIONS: The SCHK and SCHC goats exerted more efforts to maintain their redox homeostasis and to ensure the production performance than the HEAL goats during their periparturient period, probably owing to more intense fat mobilization and lipid peroxidation in the former. BioMed Central 2021-07-06 /pmc/articles/PMC8258950/ /pubmed/34229683 http://dx.doi.org/10.1186/s12917-021-02947-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Huang, Yan
Wen, Jing
Kong, Yezi
Zhao, Chenxu
Liu, Siqi
Liu, Yaoquan
Li, Lan
Yang, Jiaqi
Zhu, Xiaoyan
Zhao, Baoyu
Cao, Binyun
Wang, Jianguo
Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia
title Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia
title_full Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia
title_fullStr Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia
title_full_unstemmed Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia
title_short Oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia
title_sort oxidative status in dairy goats: periparturient variation and changes in subclinical hyperketonemia and hypocalcemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258950/
https://www.ncbi.nlm.nih.gov/pubmed/34229683
http://dx.doi.org/10.1186/s12917-021-02947-1
work_keys_str_mv AT huangyan oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT wenjing oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT kongyezi oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT zhaochenxu oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT liusiqi oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT liuyaoquan oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT lilan oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT yangjiaqi oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT zhuxiaoyan oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT zhaobaoyu oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT caobinyun oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia
AT wangjianguo oxidativestatusindairygoatsperiparturientvariationandchangesinsubclinicalhyperketonemiaandhypocalcemia