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Integrated in silico MS-based phosphoproteomics and network enrichment analysis of RASopathy proteins
BACKGROUND: RASopathies are a group of syndromes showing clinical overlap caused by mutations in genes affecting the RAS-MAPK pathway. Consequent disruption on cellular signaling leads and is driven by phosphoproteome remodeling. However, we still lack a comprehensive picture of the different key pl...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258961/ https://www.ncbi.nlm.nih.gov/pubmed/34229750 http://dx.doi.org/10.1186/s13023-021-01934-x |