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Stereoselective ketamine effect on cardiac output: a population pharmacokinetic/pharmacodynamic modelling study in healthy volunteers

BACKGROUND: Ketamine has cardiac excitatory side-effects. Currently, data on the effects of ketamine and metabolite concentrations on cardiac output are scarce. We therefore developed a pharmacodynamic model derived from data from a randomised clinical trial. The current study is part of a larger cl...

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Detalles Bibliográficos
Autores principales:	Kamp, Jasper, van Velzen, Monique, Aarts, Leon, Niesters, Marieke, Dahan, Albert, Olofsen, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Cardiovascular
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258972/ https://www.ncbi.nlm.nih.gov/pubmed/33896589 http://dx.doi.org/10.1016/j.bja.2021.02.034

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