Derepression of inflammation-related genes link to microglia activation and neural maturation defect in a mouse model of Kleefstra syndrome

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Haploinsufficiency of EHMT1, which encodes histone H3 lysine 9 (H3K9) methyltransferase G9a-like protein (GLP), causes Kleefstra syndrome (KS), a complex disorder of developmental delay and intellectual disability. Here, we examined whether postnatal supply of GLP can reverse the neurological phenot...

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Detalles Bibliográficos
Autores principales: Yamada, Ayumi, Hirasawa, Takae, Nishimura, Kayako, Shimura, Chikako, Kogo, Naomi, Fukuda, Kei, Kato, Madoka, Yokomori, Masaki, Hayashi, Tetsutaro, Umeda, Mana, Yoshimura, Mika, Iwakura, Yoichiro, Nikaido, Itoshi, Itohara, Shigeyoshi, Shinkai, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258976/
https://www.ncbi.nlm.nih.gov/pubmed/34258564
http://dx.doi.org/10.1016/j.isci.2021.102741
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