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TRAFIC: statistical design and analysis plan for a pragmatic early phase 1/2 Bayesian adaptive dose escalation trial in rheumatoid arthritis

BACKGROUND: Adaptive model-based dose-finding designs have demonstrated advantages over traditional rule-based designs but have increased statistical complexity but uptake has been slow especially outside of cancer trials. TRAFIC is a multi-centre, early phase trial in rheumatoid arthritis incorpora...

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Detalles Bibliográficos
Autores principales:	Cole, M., Yap, C., Buckley, C., Ng, W. F., McInnes, I., Filer, A., Siebert, S., Pratt, A., Isaacs, J. D., Stocken, D. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Study Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259060/ https://www.ncbi.nlm.nih.gov/pubmed/34229728 http://dx.doi.org/10.1186/s13063-021-05384-5

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