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On the feasibility of wireless radio frequency ablation using nanowire antennas

Radio frequency ablation (RFA) is a proven technique for eliminating cancerous or dysfunctional tissues in the body. However, the delivery of RFA electrodes to deep tissues causes damage to overlying healthy tissues, while a minimally invasive RFA technique would limit damage to targeted tissues alo...

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Detalles Bibliográficos
Autores principales: Rommelfanger, Nicholas J., Hong, Guosong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259129/
https://www.ncbi.nlm.nih.gov/pubmed/34262798
http://dx.doi.org/10.1063/5.0053189
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author Rommelfanger, Nicholas J.
Hong, Guosong
author_facet Rommelfanger, Nicholas J.
Hong, Guosong
author_sort Rommelfanger, Nicholas J.
collection PubMed
description Radio frequency ablation (RFA) is a proven technique for eliminating cancerous or dysfunctional tissues in the body. However, the delivery of RFA electrodes to deep tissues causes damage to overlying healthy tissues, while a minimally invasive RFA technique would limit damage to targeted tissues alone. In this manuscript, we propose a wireless RFA technique relying on the absorption of radio frequencies (RFs) by gold nanowires in vivo and the deep penetration of RF into biological tissues. Upon optimizing the dimensions of the gold nanowires and the frequency of the applied RF for breast cancer and myocardium tissues, we find that heating rates in excess of 2000 K/s can be achieved with high spatial resolution in vivo, enabling short heating durations for ablation and minimizing heat diffusion to surrounding tissues. The results suggest that gold nanowires can act as “radiothermal” agents to concentrate heating within targeted tissues, negating the need to implant bulky electrodes for tissue ablation.
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spelling pubmed-82591292021-07-12 On the feasibility of wireless radio frequency ablation using nanowire antennas Rommelfanger, Nicholas J. Hong, Guosong APL Mater Articles Radio frequency ablation (RFA) is a proven technique for eliminating cancerous or dysfunctional tissues in the body. However, the delivery of RFA electrodes to deep tissues causes damage to overlying healthy tissues, while a minimally invasive RFA technique would limit damage to targeted tissues alone. In this manuscript, we propose a wireless RFA technique relying on the absorption of radio frequencies (RFs) by gold nanowires in vivo and the deep penetration of RF into biological tissues. Upon optimizing the dimensions of the gold nanowires and the frequency of the applied RF for breast cancer and myocardium tissues, we find that heating rates in excess of 2000 K/s can be achieved with high spatial resolution in vivo, enabling short heating durations for ablation and minimizing heat diffusion to surrounding tissues. The results suggest that gold nanowires can act as “radiothermal” agents to concentrate heating within targeted tissues, negating the need to implant bulky electrodes for tissue ablation. AIP Publishing LLC 2021-07-01 /pmc/articles/PMC8259129/ /pubmed/34262798 http://dx.doi.org/10.1063/5.0053189 Text en © 2021 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Articles
Rommelfanger, Nicholas J.
Hong, Guosong
On the feasibility of wireless radio frequency ablation using nanowire antennas
title On the feasibility of wireless radio frequency ablation using nanowire antennas
title_full On the feasibility of wireless radio frequency ablation using nanowire antennas
title_fullStr On the feasibility of wireless radio frequency ablation using nanowire antennas
title_full_unstemmed On the feasibility of wireless radio frequency ablation using nanowire antennas
title_short On the feasibility of wireless radio frequency ablation using nanowire antennas
title_sort on the feasibility of wireless radio frequency ablation using nanowire antennas
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259129/
https://www.ncbi.nlm.nih.gov/pubmed/34262798
http://dx.doi.org/10.1063/5.0053189
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